Nanoparticles in Blood: Understanding and Controlling Protein Corona for Optimized Nanomedicine

NCT ID: NCT05690542

Last Updated: 2023-01-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-02-28

Study Completion Date

2024-01-31

Brief Summary

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The main objective is to study the effect of engineered nanoparticles SPIONs (superparamagnetic iron oxide) on hemostasis. Nanoparticles will be incubated in blood and platelet aggregation will be measured. In parallel, nanoparticles will also be incubated in blood and then plasma proteins adsorbed on them will be separated and analyzed. The proteins found on the nanoparticles will be linked to the platelet aggregation observed to help developing innovative protein functionalized nanoprobes for optimized nanomedicine.

Detailed Description

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Conditions

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Coagulation Tests

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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patients from intensive care units

patients with hemostasis disorders (coagulation and/or platelets), antiplatelet and/or anticoagulant treatment

blood tests

Intervention Type OTHER

evaluate the possible impact of iron oxide nanoparticles (superparamagnetic iron oxide = SPIONs) (N=10) in the blood circulation;

controls

healthy people

blood tests

Intervention Type OTHER

evaluate the possible impact of iron oxide nanoparticles (superparamagnetic iron oxide = SPIONs) (N=10) in the blood circulation;

Interventions

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blood tests

evaluate the possible impact of iron oxide nanoparticles (superparamagnetic iron oxide = SPIONs) (N=10) in the blood circulation;

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* all people

Exclusion Criteria

* patient under 18 years old, legal protection measure, pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU DIJON BOURGOGNE - laboratoire mixte

Dijon, , France

Site Status

Countries

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France

Central Contacts

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DE MAISTRE Emmanuel

Role: CONTACT

380293257 ext. +33

Facility Contacts

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DE MAISTRE Emmanuel

Role: primary

380293257 ext. +33

Other Identifiers

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DEMAISTRE CNRS 2022

Identifier Type: -

Identifier Source: org_study_id

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