Platelet PAR-1 Activation in Health and Diabetes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-01

Study Completion Date

2021-02-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Platelet activation has been associated with bad events like heart attack and stroke. There are a variety of platelet activators that regulate how active a platelet is. We are interested in Protease-activated receptors (PAR)-1. We are currently studying PAR-1 activation in persons with severe peripheral artery disease. We seek, through this project, to understand PAR-1 activation in persons without peripheral artery disease. As many patients with peripheral artery disease have diabetes, we will also evaluate PAR-1 activation in persons with type 2 diabetes. In addition we will assess the impact of the glucagon-like peptide (GLP)-1 signaling pathway on platelet activation. Levels of platelet activation will be determined using platelet aggregation experiments and assessment of platelet-monocyte aggregates in peripheral blood.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

NCT05009862

Peripheral Arterial Disease

ACTIVE_NOT_RECRUITING PHASE4

Neuroinflammation in Asymptomatic Carotid Artery Disease - Imaging Substudy

NCT05238961

Critical Asymptomatic Carotid Artery Disease Non-Critical Asymptomatic Carotid Artery Disease

RECRUITING PHASE1

TRACER [F-18] RDG-K5 Carotid Plaque Imaging Study

NCT03364270

Carotid Arteries

COMPLETED PHASE2

Carotid Atherosclerotic Plaque Study

NCT00214006

Atherosclerosis

COMPLETED

Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

NCT03202823

Carotid Stenosis

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Type 2 Diabetes Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy Subjects

Subjects will have a single visit where a short medical history/list of current medications and single blood draw will be performed.

No interventions assigned to this group

Type 2 Diabetic Subjects

Subjects will have a single visit where a short medical history/list of current medications and single blood draw will be performed.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Healthy men and women ≥60 years of age OR
* Type 2 diabetic men and women ≥60 years of age

Exclusion Criteria

* Active cancer
* Prior myocardial infarction, prior stroke, diagnosed peripheral artery disease
* Severe liver (cirrhosis, cancer, or end-stage liver disease), kidney disease (eGFR \<30 cc/min).
* Pregnancy or lactation
* Active vasculitis
* Anticipated lifespan \< 2 years
* Current use of a DOAC

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes