Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

520 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-01

Study Completion Date

2023-05-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.

The main questions to be answered are:

1. What is the incidence of problem gambling in this population?
2. What are the predictors of problem gambling in this population?

To do so, putative predictors of problem gambling will be analyzed using Cox regression models:

* Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment);
* Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders);
* Antipsychotic use (first/second-generation, third-generation \[aripiprazole, brexpiprazole, cariprazine\]);
* Prior gambling history.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients

NCT05365347

Psychosis Alcohol Use Disorder

RECRUITING NA

Impact of Cannabis Consumption on the Course, Modalities of Hospitalization and the Short-term Prognosis of Inpatients Suffering From Psychotic Symptoms

NCT06314204

Psychotic; Disorder, Cannabis

RECRUITING

Service User and Staff Views on Digital Remote Monitoring for Psychosis

NCT05670197

Psychosis Schizophrenia Schizoaffective Disorder

COMPLETED

Dimensional and Developmental Profiles of Psychosis in Children and Adolescents

NCT04370730

Schizophrenia Psychotic Disorders

RECRUITING NA

mHealth for Psychosis Help-seeking

NCT05905601

Psychosis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

All Cox regression models will be adjusted for site-effect. Further multivariable models will be constructed to examine the association between antipsychotic use (as continuous exposure) and incident PBG using the directed acyclic graphs approach to adjust for confounders.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Gambling Disorder Psychotic Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

First-episode psychosis patients

All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.

Antipsychotic use

Intervention Type DRUG

Use of first/second generation antipsychotics, use of third-generation antipsychotics, use of aripiprazole specifically

Psychiatric comorbidities

Intervention Type OTHER

Substance use disorders, cluster B personality disorders, anxiety disorder, major depressive disorder, attention-deficit/hyperactivity disorder, tobacco smoking

Sociodemographics/socioeconomic status

Intervention Type OTHER

Age, gender identity, ethnicity, highest educational attainment, employment, at school, homelessness, in a relationship

Gambling history

Intervention Type OTHER

Non-problematic gambling at the time of admission and/or previous 12 months

Clinical variables

Intervention Type OTHER

Main psychiatric diagnosis, history of psychiatric hospitalizations, severity of illness (CGI-S), functioning (SOFAS), concomitant psychotropic medications use

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Antipsychotic use

Use of first/second generation antipsychotics, use of third-generation antipsychotics, use of aripiprazole specifically

Intervention Type DRUG

Psychiatric comorbidities

Substance use disorders, cluster B personality disorders, anxiety disorder, major depressive disorder, attention-deficit/hyperactivity disorder, tobacco smoking

Intervention Type OTHER

Sociodemographics/socioeconomic status

Age, gender identity, ethnicity, highest educational attainment, employment, at school, homelessness, in a relationship

Intervention Type OTHER

Gambling history

Non-problematic gambling at the time of admission and/or previous 12 months

Intervention Type OTHER

Clinical variables

Main psychiatric diagnosis, history of psychiatric hospitalizations, severity of illness (CGI-S), functioning (SOFAS), concomitant psychotropic medications use

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 to 35 years old;
* Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).

Exclusion Criteria

* Active/prior PBG at te time of admission;
* Loss to follow-up within first three months;
* DSM-5 diagnosis of psychotic disorder due to a medical condition;
* Severe intellectual disability.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No