Radiographic Prediction of the Nerve Origin of Neck Peripheral Nerve Sheath Tumors

NCT ID: NCT05684835

Last Updated: 2023-01-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2023-06-01

Brief Summary

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Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors. This study is a retrospective cohort aimed to predict the nerve origin of neck peripheral nerve sheath tumors. Accurate preoperative identification of the nerve origin can improve surgical outcomes and patient counseling

Detailed Description

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Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors (PNSTs). Accurate preoperative identification of the nerve origin (NO) can improve surgical outcomes and patient counseling. This study aims to predict the NO of neck PNSTs with radiographic analysis. This study is a retrospective cohort analysis. Radiographic parameters will be reviewed and the sensitivity, specificity, accuracy of NO prediction will be evaluated.

Conditions

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Peripheral Nerve Sheath Tumors Schwannoma of Neck

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Vagus nerve tumor group

patients with neck peripheral nerve sheath tumors originating from the vagus nerve

Excision

Intervention Type PROCEDURE

All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.

Sympathetic nerve tumor group

patients with neck peripheral nerve sheath tumors originating from the sympathetic nerve

Excision

Intervention Type PROCEDURE

All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.

Cervical spinal nerve tumor group

patients with neck peripheral nerve sheath tumors originating from the cervical spinal nerve

Excision

Intervention Type PROCEDURE

All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.

Interventions

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Excision

All patients underwent surgery under general anesthesia and intraoperative neuromonitoring according to the preoperatively predicted NO. Using an anterior cervical approach, the tumor was delineated after identifying the relationships among the great vessels, nerves, and tumors. The NO was confirmed intraoperatively. Sharp dissection was performed meticulously to enucleate the tumor from the NO to preserve most nerve fibers.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with clinical diagnosis of neck peripheral nerve sheath tumors.
* Patients received surgery January 2008 and December 2022.
* The nerve origin of peripheral nerve sheath tumor must be intraoperatively confirmed.

Exclusion Criteria

* Previous anterior neck surgery.
* Malignant disease.
* Prior neck radiation.
* Undetermined intraoperative nerve origin.
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cheng-Kung University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Chi Chen Huang

Attending doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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National Cheng-Kung University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chi-Chen Huang, MD

Role: CONTACT

06-2353535 ext. 258821

Facility Contacts

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Chi-Chen Huang, MD

Role: primary

06-2353535 ext. 258821

References

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Wong CE, Huang CC, Chuang MT, Lee PH, Chen LY, Hsu HH, Huang CY, Wang LC, Lee JS. Quantification of vessel separation using the carotid-jugular angle to predict the nerve origin of neck peripheral nerve sheath tumours: a pooled analysis of cases from the literature and a single-center cohort. Int J Surg. 2023 Sep 1;109(9):2704-2713. doi: 10.1097/JS9.0000000000000491.

Reference Type DERIVED
PMID: 37204443 (View on PubMed)

Other Identifiers

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A-ER-109-209

Identifier Type: -

Identifier Source: org_study_id

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