Multiparametric Magnetic Resonance Imaging (MRI) in Medullary Sponge Kidney
NCT ID: NCT05682053
Last Updated: 2025-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
33 participants
INTERVENTIONAL
2023-03-27
2024-01-08
Brief Summary
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Medullary sponge kidney disease is a congenital disorder caracterised by tubular ectasia and cystic dilatation of the collecting ducts in the pericalyceal region of the renal pyramids, which can lead to nephrolithiasis and frequently associated with impaired tubular function such as distal renal tubular acidosis.
The disease knowledge is limited, especially about origin, diagnosis, and physiopathology of the disease.
The disease is associated with impaired tubular function such as distal renal tubular acidosis, hypocitraturia, hypercalciuria, which suggest altered kidney medulla function.
Multiparametric MRI may provide further informations about the physiopathology and help in earlier diagnosis of the medullary sponge kidney.
Objective :
The aim of this study is to test the hypothesis that early kidney medulla function alteration in medullary sponge kidney can be detected and characterised with multiparametric MRI. We are expecting to see in medullary sponge kidney a decreased oxygenation content in BOLD MRI (Blood oxygenation level dependent magnetic resonance imaging), and decreased ADC (Apparent diffusion coefficient) value in the medulla.
Design :
A monocentric prospective case/control study will be conducted in adults with medullary sponge kidney. Controls are adults patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone attending a renal exploration.
After a screening visit, patients included will be evaluated on one day with lithiasis assessment and measurement of glomerular filtration (Urinary collection of the last 24 hours, Urine sample, Blood sample) and they will perform multiparametric magnetic resonance imaging of the kidneys.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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patients with medullary sponge kidney
Patients with medullary sponge kidney attending medical consultation
Multiparametic MRI
patients will have a Multiparametric MRI
Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone
Patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone attending a renal exploration.
Multiparametic MRI
patients will have a Multiparametric MRI
Interventions
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Multiparametic MRI
patients will have a Multiparametric MRI
Eligibility Criteria
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Inclusion Criteria
* Patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone
* consent signed
* effective contraceptive method for women
* affiliated to social insurance scheme
Exclusion Criteria
* polycystic kidney diseases
* Chronic kidney disease (GFR \< 60 mL/min/1,73m² )
* MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible)
* Weight\> 130 kg
* pregnancy
* legal protection measure (guardianship, curatorship)
* Deprived of liberty by a judicial or administrative decision
* subject participating in another research that may interfere with the research and including an exclusion period still in progress at inclusion
18 Years
ALL
No
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Locations
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Hôpital Edouard Herriot
Lyon, , France
Countries
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References
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Tournebize C, De Mul A, Abid N, Portefaix A, Pacaud S, Schleef M, Derain-Dubourg L, Rouviere O, Lemoine S. Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities. J Nephrol. 2025 Nov;38(8):2363-2373. doi: 10.1007/s40620-025-02413-3. Epub 2025 Sep 19.
Other Identifiers
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2022-A01467-36
Identifier Type: OTHER
Identifier Source: secondary_id
69HCL22_0366
Identifier Type: -
Identifier Source: org_study_id
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