Surgical Outcome of Dorsolumbar Intradural Extramedullary Spinal Cord Tumors

NCT ID: NCT05678608

Last Updated: 2023-01-10

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-13
• Study Completion Date: 2023-05-31

Brief Summary

Primary spinal cord tumors constitute 2-4% of all central nervous system neoplasms; they are classfied as extradural, intradural extramedullary (IDEM: 65%), and intramedullary The most commonly seen IDEM tumors are schwannomas, neurofibromas, and meningiomas. [1] The less frequently encountered IDEM tumors include ependymomas, lipomas, hemangiomas, metastatic deposits, paragangliomas, nerve sheath myxomas, and vascular tumors.[2] Spinal cord tumors can cause different signs and symptoms, especially as tumors grow. The tumors may affect spinal cord or the nerve roots, blood vessels or bones of spine. Signs and symptoms may include: Pain at the site of the tumor due to tumor growth Back pain, often radiating to other parts of body Feeling less sensitive to pain, heat and cold Loss of bowel or bladder function Difficulty walking, muscle weakness .

MRI is the investigation of choice,however other investigation such CT or X ray are important to ensure stability of the vertebral column and the optimal management is gross total excision for symptomatic lesions.[3,4] Over the years, there has been no significant change in the clinical symptoms and pathology of IDEM tumors. However, there have been dramatic improvements in the diagnosis and treatment with the advances of radiological and surgical techniques. Despite advances in operative techniques and neuroimaging, the morbidity associated with the resection of IDEM tumors continues to be significant [5,6].

Here, we examined the surgical outcomes of 20 patients with IDEM spinal cord tumors operated in Neurosurgery department at Sohag university Hospital

Conditions

Spinal Cord Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

spinal cord tumors group

Group Type: EXPERIMENTAL

surgical excision

Intervention Type: PROCEDURE

posterior midline approach and total excision for spinal cord tumors

Interventions

surgical excision

posterior midline approach and total excision for spinal cord tumors

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• patients with intradural extramedullary lesion in dorsolumber region

Exclusion Criteria

• previous history of spinal surgery
• unfit medical patients
• multiple level affection
• associated cervical lesion
• unstable segment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Mohamed AHmed Kassem

demonstrator at neurosurgery department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Sohag University Hospital

Sohag, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

mohamed M kassem, demonstrator

Role: CONTACT

mohamed011152@med.sohag.edu.eg

010980-03153

mohammed M abd el-Aal, professor

Role: CONTACT

01123728094

Facility Contacts

Magdy M Amin, professor

Role: primary

References

Song KW, Shin SI, Lee JY, Kim GL, Hyun YS, Park DY. Surgical results of intradural extramedullary tumors. Clin Orthop Surg. 2009 Jun;1(2):74-80. doi: 10.4055/cios.2009.1.2.74. Epub 2009 May 27.

Reference Type: BACKGROUND

PMID: 19885058 (View on PubMed)

Abul-Kasim K, Thurnher MM, McKeever P, Sundgren PC. Intradural spinal tumors: current classification and MRI features. Neuroradiology. 2008 Apr;50(4):301-14. doi: 10.1007/s00234-007-0345-7. Epub 2007 Dec 15.

Reference Type: BACKGROUND

PMID: 18084751 (View on PubMed)

Narayan S, Rege SV, Gupta R. Clinicopathological Study of Intradural Extramedullary Spinal Tumors and Its Correlation With Functional Outcome. Cureus. 2021 Jun 18;13(6):e15733. doi: 10.7759/cureus.15733. eCollection 2021 Jun.

Reference Type: BACKGROUND

PMID: 34285844 (View on PubMed)

Other Identifiers

soh-med-22-12-02

Identifier Type: -

Identifier Source: org_study_id