Ocular Changes With Alpha-2 Receptor Agonist.

NCT ID: NCT05670015

Last Updated: 2023-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-01

Study Completion Date

2023-09-22

Brief Summary

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selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.

Detailed Description

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In this research, we will analyze the effect of selective alpha-2 receptor agonists on the human eye and investigate ocular changes over 6 months after its topical use.

Conditions

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Glaucoma, Suspect Aberration, Corneal Wavefront

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Glaucoma suspect group

Cases diagnosed as glaucoma suspect

Group Type ACTIVE_COMPARATOR

Low dosage selective alpha-2 receptor agonists topical eyedrop

Intervention Type DRUG

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.2% concentration.

High dosage selective alpha-2 receptor agonists topical eyedrop

Intervention Type DRUG

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.02% concentration.

Post-refractive surgery group

Cases had undergone refractive surgery

Group Type ACTIVE_COMPARATOR

Low dosage selective alpha-2 receptor agonists topical eyedrop

Intervention Type DRUG

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.2% concentration.

High dosage selective alpha-2 receptor agonists topical eyedrop

Intervention Type DRUG

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.02% concentration.

Interventions

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Low dosage selective alpha-2 receptor agonists topical eyedrop

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.2% concentration.

Intervention Type DRUG

High dosage selective alpha-2 receptor agonists topical eyedrop

Using selective alpha-2 receptor agonists eyedrop in both groups with 0.02% concentration.

Intervention Type DRUG

Other Intervention Names

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Topical selective alpha-2 receptor agonists Topical selective alpha-2 receptor agonists

Eligibility Criteria

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Inclusion Criteria

* Glaucoma suspect cases.
* post-refractive surgery cases.

Exclusion Criteria

* Cases with prostatic hyperplasia or diabetics that may alter the measurements of pupillary diameter.
* Cases with previous history of any retinal intervention or other drugs that may alter intraocular pressure measurements.
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Abdelshafy

Assistant professor of Ophthalmology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ahmed A Abdelshafy, MD

Role: PRINCIPAL_INVESTIGATOR

Benha University

Locations

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Ahmed Abdelshafy

Banhā, QA, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Ahmed Abdelshafy, MD

Role: CONTACT

01222328766

Marwa Abdelshafy, MD

Role: CONTACT

01008128810

Facility Contacts

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Ahmed Abdelshafy

Role: primary

01222328766

Other Identifiers

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RC-2-2023

Identifier Type: -

Identifier Source: org_study_id

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