Evaluation Of Stress Response In Diabetic Hypertensive Patients
NCT ID: NCT05662930
Last Updated: 2022-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
62 participants
OBSERVATIONAL
2016-06-01
2018-09-04
Brief Summary
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The research was conducted by solving an arithmetic task as a stress test in 62 patients with HT+DM and HT that are being treated in the outpatient clinic of Medical Pharmacology and Clinical Pharmacology Department at Istanbul University, Istanbul Medical Faculty Hospital.
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Detailed Description
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Salivary cortisol was measured using the electro-chemiluminescence immunoassay.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Hypertension + Diabetes Mellitus (HT+DM)
Patients who fulfilled the following criteria were included in this group:
1. Using antihypertensive treatment for the last 3 months
2. Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months
3. Being between the ages of 40-65
4. Being male
5. Having signed the informed consent form
First arithmetic problem solving
In a quiet environment, a white paper in A4 format was placed in front of the patient on the table, and the patients were asked to subtract the number 3 from 2907 for 100 seconds.
The researcher was standing in front of the patient and asks to make corrections by giving a warning whenever the patient made a mistake in the calculation.
Second arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the first subtraction process, patients were asked to subtract 7 from 6828 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Third arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 13 from 9561 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fourth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 8 from 5113 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fifth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 14 from 8318 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Sixth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 17 from 9994 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Hypertension (HT)
Patients who fulfilled the following criteria were included in this group:
1. Using antihypertensive treatment for the last 3 months
2. Being between the ages of 40-65
3. Being male
4. Having signed the informed consent form
First arithmetic problem solving
In a quiet environment, a white paper in A4 format was placed in front of the patient on the table, and the patients were asked to subtract the number 3 from 2907 for 100 seconds.
The researcher was standing in front of the patient and asks to make corrections by giving a warning whenever the patient made a mistake in the calculation.
Second arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the first subtraction process, patients were asked to subtract 7 from 6828 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Third arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 13 from 9561 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fourth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 8 from 5113 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fifth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 14 from 8318 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Sixth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 17 from 9994 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Interventions
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First arithmetic problem solving
In a quiet environment, a white paper in A4 format was placed in front of the patient on the table, and the patients were asked to subtract the number 3 from 2907 for 100 seconds.
The researcher was standing in front of the patient and asks to make corrections by giving a warning whenever the patient made a mistake in the calculation.
Second arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the first subtraction process, patients were asked to subtract 7 from 6828 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Third arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 13 from 9561 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fourth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 8 from 5113 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Fifth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 14 from 8318 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Sixth arithmetic problem solving
In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 17 from 9994 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Eligibility Criteria
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Inclusion Criteria
2. Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months
3. Being between the ages of 40-65
4. Being male
5. Having signed the informed consent form
Exclusion Criteria
2. Patients younger than 40 years old or older than 65 years old
3. Uncontrolled blood pressure (SBP\>140 mmHg, DBP\>90 mmHg)
4. Using antipsychotic medication
5. Using current treatment for less than 3 months
6. Having a previous MI
7. Having a previous stroke
8. Having a lung disease
9. Having organ failure
10. Having Cushing's disease
11. Having aldosteronism
12. Failure to sign the informed consent form
40 Years
65 Years
MALE
No
Sponsors
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Istanbul University
OTHER
Responsible Party
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Iliriana Alloqi Tahirbegolli
Principal investigator
Principal Investigators
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Iliriana Alloqi Tahirbegolli, Prof.Ass.Dr.
Role: PRINCIPAL_INVESTIGATOR
Istanbul University
Locations
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Istanbul University
Istanbul, , Turkey (Türkiye)
Countries
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References
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Alloqi Tahirbegolli I, Tahirbegolli B, Sen S, Sayin B, Kaskal M, Uresin AY. Evaluation of Stress Response in Middle-Aged Male Diabetic Hypertensive Patients. J Clin Endocrinol Metab. 2023 Aug 18;108(9):2307-2314. doi: 10.1210/clinem/dgad122.
Other Identifiers
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22939
Identifier Type: -
Identifier Source: org_study_id
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