INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures

NCT ID: NCT05642026

Last Updated: 2025-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-23

Study Completion Date

2027-02-01

Brief Summary

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This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous/oral inpatient and oral outpatient) alone for patients with multiple rib fractures. The objective of this study is to analyze the effect of continuous intercostal nerve block (CINB) in the treatment of patients admitted to the adult trauma service with rib fractures. The effectiveness of CINB as adjunctive treatment will be compared to standard medical therapy involving nonsteroidal and intravenous/oral opioid medications.

Detailed Description

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Conditions

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Rib Fractures

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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continuous intercostal nerve block (CINB)

patients admitted to the adult trauma service with rib fractures who are receiving CINB

Group Type EXPERIMENTAL

Ropivacaine

Intervention Type DRUG

Patients in this group will receive CINB (continuous local intercostal infusion of 0.2% Ropivacaine). A single catheter will be placed for short segment involvement and two catheters will be placed in series for longer segments of involvement. If necessary and as part of standard of care, CINB treatment will continue after patient discharge. The administration of CINB therapy will continue in the same manner as inpatient therapy.

Non steroidal anti-inflammatory drug and opioids

Intervention Type DRUG

Patients in this group receive nonsteroidal and opioid pain medications (intravenous/oral inpatient and oral outpatient) per standard of care.

standard medical care

patients admitted to the adult trauma service with rib fractures who are receiving standard medical care

Group Type ACTIVE_COMPARATOR

Non steroidal anti-inflammatory drug and opioids

Intervention Type DRUG

Patients in this group receive nonsteroidal and opioid pain medications (intravenous/oral inpatient and oral outpatient) per standard of care.

Interventions

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Ropivacaine

Patients in this group will receive CINB (continuous local intercostal infusion of 0.2% Ropivacaine). A single catheter will be placed for short segment involvement and two catheters will be placed in series for longer segments of involvement. If necessary and as part of standard of care, CINB treatment will continue after patient discharge. The administration of CINB therapy will continue in the same manner as inpatient therapy.

Intervention Type DRUG

Non steroidal anti-inflammatory drug and opioids

Patients in this group receive nonsteroidal and opioid pain medications (intravenous/oral inpatient and oral outpatient) per standard of care.

Intervention Type DRUG

Other Intervention Names

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Naropin

Eligibility Criteria

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Inclusion Criteria

* Subjects will be at least 18 years old
* Subjects will have 2 or more identified rib fractures
* Subjects will be willing to provide informed consent for procedure
* Subjects will be identified as appropriate for initiation of continuous nerve block therapy for treatment of rib fracture associated pain.

Exclusion Criteria

* Documented allergy to study medication
* Epidural catheter use
* Prisoners
* Refusal of CINB therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zachary Warriner

OTHER

Sponsor Role lead

Responsible Party

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Zachary Warriner

Assistant Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Zachary Warriner, MD

Role: PRINCIPAL_INVESTIGATOR

University of Kentucky

Locations

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University of Kentucky Medical Center

Lexington, Kentucky, United States

Site Status RECRUITING

Countries

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United States

Facility Contacts

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Zachary D Warriner, MD

Role: primary

8593238222

Other Identifiers

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SURMI-22-INTERCOSTAL-NB

Identifier Type: -

Identifier Source: org_study_id

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