Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

NCT ID: NCT05627219

Last Updated: 2025-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-03

Study Completion Date

2026-04-29

Brief Summary

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This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). While genetic testing has become central to prostate cancer care, African American men are less likely seek testing due to lack of awareness, cultural beliefs, financial limitations, fear of discrimination, and mistrust in the healthcare system. A network of peer genetic coaches may help address barriers, beliefs, and needs of African American men in the community and provide navigation to increase engagement in genetic testing.

Detailed Description

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PRIMARY OBJECTIVES:

I. Identify and train 6 African American (AA) men as peer genetic coaches (PGCs) for the Extending Prostate Genetic Awareness, Navigation, and Delivery (EXPAND) Network. (Train peer genetic coaches) II. Conduct a feasibility study of peer genetic coaching. (Provide individual coaching)

SECONDARY OBJECTIVE:

I. Patient-related outcomes will include change in decisional conflict for genetic counseling, acceptability/attitude toward genetic counseling and testing, and change of genetics knowledge.

OUTLINE:

AIM 1: Peer genetic coaches undergo training and education on study.

AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Conditions

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Metastatic Prostate Carcinoma Stage IIIB Prostate Cancer AJCC v8 Stage IIIC Prostate Cancer AJCC v8 Stage IV Prostate Cancer AJCC v8

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Supportive care (training, education, discussion)

AIM 1: Peer genetic coaches undergo training and education on study.

AIM 2: Patients receive an educational booklet and attend a discussion with a peer genetic coach on study.

Training and Education

Intervention Type BEHAVIORAL

Undergo training and education

Educational Intervention

Intervention Type OTHER

Receive educational booklet

Discussion

Intervention Type PROCEDURE

Attend discussion with peer genetic coach

Interventions

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Training and Education

Undergo training and education

Intervention Type BEHAVIORAL

Educational Intervention

Receive educational booklet

Intervention Type OTHER

Discussion

Attend discussion with peer genetic coach

Intervention Type PROCEDURE

Other Intervention Names

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Education for Intervention Intervention by Education Intervention through Education Intervention Educational Discuss

Eligibility Criteria

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Inclusion Criteria

* AIM 1: Are 18 years old or older
* AIM 1: Are able to read and speak English comfortably
* AIM 1: Men who have experience with both prostate cancer (PCA) and genetic counseling and testing will be a priority for training, as well as men who have considerable peer education or navigation experience
* AIM 2: Are 18 years old or older
* AIM 2: Are African American
* AIM 2: Are able to read and speak English comfortably
* AIM 2: Men who meet any one of the following criteria: (1) metastatic prostate cancer; (2) prostate cancer with high-risk features (T3 or higher, Gleason 8 or higher, node positive disease); (3) with or without a diagnosis of prostate cancer with strong family history (2 or more first-degree or second-degree relatives) with prostate cancer (particularly metastatic prostate cancer or died from prostate cancer), breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer, uterine cancer, renal cancer, urothelial cancer, or upper bowel cancer

* Children under the age of 18
* Anyone who has trouble understanding the consent or with significant anxiety detected during the consent process
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Thomas Jefferson University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Amy Leader, DrPh, MPH

Role: PRINCIPAL_INVESTIGATOR

Thomas Jefferson University

Locations

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Sidney Kimmel Cancer Center at Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Amy Leader, DrPh, MPH

Role: CONTACT

215 955-7739

Facility Contacts

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Amy Leader, DrPh, MPH

Role: primary

215 955-7739

Other Identifiers

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JT 22046

Identifier Type: OTHER

Identifier Source: secondary_id

22C.423

Identifier Type: -

Identifier Source: org_study_id

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