Lifestyle Intervention for the Reduction of Prostate Cancer Disparities Among African Americans

NCT ID: NCT04215029

Last Updated: 2025-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-27

Study Completion Date

2026-07-31

Brief Summary

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This trial studies how well a lifestyle intervention works in reducing prostate cancer disparities among African American prostate cancer patients and their spouses or romantic partners. A lifestyle intervention may help researchers learn if social support can help African American prostate cancer patients and their partners improve their quality of life, support from their partner, physical activity, diet, and inflammation.

Detailed Description

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PRIMARY OBJECTIVE:

I. To expand an existing couple-based behavioral intervention developed for African American (AA) or Hispanic men on active surveillance (Watchful Living; protocol #: 2017-0556) to AA prostate cancer (PCa) survivors who underwent active treatments to examine its feasibility of recruiting AA PCa survivor-partner dyads (N = 40 dyads) and implementing a lifestyle intervention.

SECONDARY OBJECTIVES:

I. Evaluate a preliminary efficacy of the intervention in improving quality of life, physical activity, nutrient intake, and inflammation.

II. Explore psychosocial mediators and moderators of the intervention. III. Conduct a process evaluation. IV. Assess healthcare-provider level factors (with N=15 providers) that influence both survivors' and partners' healthy lifestyle behaviors.

OUTLINE: Patients and their partners are randomized to 1 of 2 groups.

GROUP I: Patients and their partners receive an exercise plan and printed materials that includes instructions for walking or other moderate-intensity activities. Patients and their partners also receive coaching calls discussing physical activity and diet related questions, each lasting 45-60 minutes and occurring every 2 weeks for 6 months. In addition, patients and their partners complete 2 nutrition counseling sessions over 1 hour each at baseline and before month 3 with an MD Anderson registered dietitian.

GROUP II: Patients and their partners receive information/materials regarding physical activity and healthy eating.

PROVIDER INTERVIEWS: Healthcare providers participate in an interview regarding their opinions on family-focused care and its ability to improve health behaviors.

Conditions

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Cancer Survivor Partner Spouse Stage I Prostate Cancer AJCC v8 Stage II Prostate Cancer AJCC v8 Stage IIA Prostate Cancer AJCC v8 Stage IIB Prostate Cancer AJCC v8 Stage IIC Prostate Cancer AJCC v8 Stage III Prostate Cancer AJCC v8 Stage IIIA Prostate Cancer AJCC v8 Stage IIIB Prostate Cancer AJCC v8 Stage IIIC Prostate Cancer AJCC v8

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Group I (exercise plan, coaching calls, nutrition counseling)

Patients and their partners receive an exercise plan and printed materials that includes instructions for walking or other moderate-intensity activities. Patients and their partners also receive coaching calls discussing physical activity and diet related questions, each lasting 45-60 minutes and occurring every 2 weeks for 6 months. In addition, patients and their partners complete 2 nutrition counseling sessions over 1 hour each at baseline and before month 3 with an MD Anderson registered dietitian.

Group Type EXPERIMENTAL

Exercise Intervention

Intervention Type BEHAVIORAL

Receive exercise plan

Informational Intervention

Intervention Type OTHER

Receive printed exercise materials

Nutritional Assessment

Intervention Type OTHER

Complete nutrition counseling sessions

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Telephone-Based Intervention

Intervention Type BEHAVIORAL

Receive coaching calls

Group II (physical activity/healthy eating information)

Patients and their partners receive information/materials regarding physical activity and healthy eating.

Group Type ACTIVE_COMPARATOR

Informational Intervention

Intervention Type OTHER

Receive physical activity and healthy eating information/materials

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Provider Interviews (interviews)

Healthcare providers participate in an interview regarding their opinions on family-focused care and its ability to improve health behaviors.

Group Type EXPERIMENTAL

Interview

Intervention Type OTHER

Participate in interview

Interventions

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Exercise Intervention

Receive exercise plan

Intervention Type BEHAVIORAL

Informational Intervention

Receive printed exercise materials

Intervention Type OTHER

Informational Intervention

Receive physical activity and healthy eating information/materials

Intervention Type OTHER

Interview

Participate in interview

Intervention Type OTHER

Nutritional Assessment

Complete nutrition counseling sessions

Intervention Type OTHER

Questionnaire Administration

Ancillary studies

Intervention Type OTHER

Telephone-Based Intervention

Receive coaching calls

Intervention Type BEHAVIORAL

Other Intervention Names

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Dietary Assessment dietary counseling nutritional counseling

Eligibility Criteria

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Inclusion Criteria

* To be eligible, prostate cancer survivors must self-identify as black or African American
* Prostate cancer survivors must have 0-III stage prostate cancer
* Prostate cancer survivors must have completed therapy (e.g., surgery, chemotherapy \[chemo\] and/or radiation)
* Prostate cancer survivors must enroll with a spouse or a romantic partner
* Prostate cancer survivors must not meet physical activity recommendation (i.e., 150 minutes of moderate intensity physical activity per week)
* Prostate cancer survivors must be willing and able to be physically active, as determined by responses to the Physical Activity Readiness Questionnaire (PAR-Q)
* Prostate cancer survivors must not participate in another physical activity, diet, or lifestyle program
* Prostate cancer survivors must have a valid home address and telephone number
* Prostate cancer survivors must be able to access internet over a smartphone or a computer at home or other location (e.g., work, church, library, community center, etc.)
* To be eligible, spouses or romantic partners must be \>=18 years of age
* Spouses or romantic partners must enroll with a spouse or a romantic partner with prostate cancer
* Spouses or romantic partners must live together with the survivors
* Spouses or romantic partners must not have major health problems (e.g., cancer, dementia, stroke, and heart and lung diseases)
* Spouses or romantic partners must be willing and able to be physically active, as determined by responses to the Physical Activity Readiness Questionnaire (PAR-Q)
* To be eligible, healthcare providers must be currently providing care with individuals diagnosed with prostate cancer
* Any professionals such as surgical and medical oncologists, fellows, nurse practitioners, physical assistants, and primary care physicians will be eligible

Exclusion Criteria

* Prostate cancer survivors will be excluded if they are not married or partnered
* Prostate cancer survivors will be excluded if they have an active noncutaneous malignancy at any site
* Prostate cancer survivors will be excluded if they had a prior history of other cancer or have metastatic cancer
* Prostate cancer survivors will be excluded if they have planned concomitant immunotherapy, hormonal therapy, chemotherapy, or radiation therapy during the study period
* Prostate cancer survivors will be excluded if they are on active surveillance
* Prostate cancer survivors will be excluded if they enrolled in a protocol #: 2017-0556
* Prostate cancer survivors will be excluded if they are not able to understand and speak English
* Spouses or romantic partners who are not able to understand and speak English will be excluded
* Also, spouses or romantic partners who enrolled in a protocol (#2017-0556) will be excluded
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Brander Beacons Cancer Research

UNKNOWN

Sponsor Role collaborator

National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

M.D. Anderson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dalnim Cho

Role: PRINCIPAL_INVESTIGATOR

M.D. Anderson Cancer Center

Locations

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M D Anderson Cancer Center

Houston, Texas, United States

Site Status

Countries

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United States

Related Links

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http://www.mdanderson.org

MD Anderson Cancer Center Website

Other Identifiers

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NCI-2019-05912

Identifier Type: REGISTRY

Identifier Source: secondary_id

2019-0361

Identifier Type: OTHER

Identifier Source: secondary_id

2019-0361

Identifier Type: -

Identifier Source: org_study_id

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