Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) Registry

NCT ID: NCT05625607

Last Updated: 2022-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-17

Study Completion Date

2026-05-31

Brief Summary

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In recent years increasing number of mitral bioprosthesis implantation, especially in elderly population, is observed. Bioprosthetic valves are associated with a lower risk of thrombotic and bleeding adverse events compared with mechanical prostheses, but their use is limited due to their durability. After years numerous patients may develop bioprosthesis failure, requiring valve reintervention. Significantly burdened ones are oftentimes disqualified or not referred to surgery redo. An emerging treatment method for these patients is transcatheter mitral valve-in-valve implantation as an alternative to re-operation. This technique is applied with the use of devices previously dedicated to transcatheter aortic valve implantation (TAVI). Recent papers prove that transcatheter mitral valve replacement (TMVR) is a safe and effective procedure when performed in a selected group of high-surgical-risk patients. However, data regarding the Polish population are limited. Therefore, the aim of the study is to create a nationwide registry, collecting data from all Polish centers performing TMVR in order to describe the population of patients developing mitral bioprosthesis failure, evaluate their follow-up after TMVR as well as results of the transcatheter valvular intervention and identify potential limitations of the procedure.

Detailed Description

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Conditions

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Mitral Insufficiency Mitral Stenosis Mitral Stenosis With Insufficiency Heart Failure Bioprosthesis Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Transcatheter mitral valve-in-valve implantation

Transcatheter transfemoral mitral valve-in-valve implantation is an alternative for surgery redo in high-surgical-risk patients with bioprosthetic valve failure. The procedure is performed via femoral vein access. By the transseptal puncture (in the postero-inferior part of the interatrial septum) and balloon septostomy, the bioprosthetic valve is introduced through the degenerative valve into the left ventricle. The valve is expanded in the mitral position during rapid ventricle pacing.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Failing surgically implanted mitral bioprosthetic valve demonstrating ≥ moderate stenosis and/or ≥ moderate insufficiency
* Qualification for TMVR by decision of the local Heart Team
* Patient provided written informed consent

Exclusion Criteria

\- Disqualification from TMVR
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Cardiology, Warsaw, Poland

OTHER

Sponsor Role collaborator

Medical University of Bialystok

OTHER

Sponsor Role collaborator

University of Opole

OTHER

Sponsor Role collaborator

Medical University of Gdansk

OTHER

Sponsor Role collaborator

Medical University of Silesia

OTHER

Sponsor Role collaborator

Medical University of Lodz

OTHER

Sponsor Role collaborator

Medical University of Warsaw

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Medical University of Białystok

Bialystok, , Poland

Site Status RECRUITING

Medical University of Gdańsk

Gdansk, , Poland

Site Status RECRUITING

Medical University of Silesia

Katowice, , Poland

Site Status RECRUITING

Medical University of Łódź

Lodz, , Poland

Site Status RECRUITING

Medical University of Opole

Opole, , Poland

Site Status RECRUITING

Medical University of Warsaw

Warsaw, , Poland

Site Status RECRUITING

Institute of Cardiology

Warsaw, , Poland

Site Status RECRUITING

Countries

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Poland

Facility Contacts

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Paweł Kralisz, MD, PhD

Role: primary

+48 85 746 84 96

Dariusz Jagielak, MD, PhD

Role: primary

+48 58 584 42 00

Wojciech Wojakowski, MD,PhD

Role: primary

+48 32 359 86 90

Andrzej Walczak, MD, PhD

Role: primary

+48 42 201 44 60

Jerzy Sacha, MD, PhD

Role: primary

+48 77 45 20 660

Maciej Mazurek, MD

Role: primary

+48 510265843

Adam Witkowski, MD, PhD

Role: primary

+48 22 343 43 42

Marcin Demkow, MD, PhD

Role: backup

References

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Stone GW, Adams DH, Abraham WT, Kappetein AP, Genereux P, Vranckx P, Mehran R, Kuck KH, Leon MB, Piazza N, Head SJ, Filippatos G, Vahanian AS; Mitral Valve Academic Research Consortium (MVARC). Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: A consensus document from the Mitral Valve Academic Research Consortium. Eur Heart J. 2015 Aug 1;36(29):1878-91. doi: 10.1093/eurheartj/ehv333. Epub 2015 Jul 13.

Reference Type BACKGROUND
PMID: 26170468 (View on PubMed)

Other Identifiers

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WUM-MViV

Identifier Type: -

Identifier Source: org_study_id

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