Respiratory Muscles Electromyography in Patients With Covid-19
NCT ID: NCT05572853
Last Updated: 2024-03-06
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Total Enrollment
74 participants
Study Classification
OBSERVATIONAL
Study Start Date
2021-02-25
Study Completion Date
2023-08-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This research was characterized as a cross-sectional observational study, following the recommendations of the STROBE instrument. Therefore, it was conducted in the Intensive Care Unit of Otávio de Freitas Hospital (HOF) in Recife/PE, with patients over 18 years old who had a clinical diagnosis of COVID-19, using two methods of oxygen therapy (Nasal Oxygen Therapy) and (non-rebreather mask). Consequently, clinical evaluations were performed regarding the disease, severity of COVID-19, perception of respiratory effort, and electromyography of respiratory muscles.
1. Leading Question: How does the recruitment pattern of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia caused by COVID-19 behave when assessed through EMGs, considering the SpO2/FiO2 ratio as the analysis parameter?
2. Leading Question: Is there a relationship between the respiratory work estimated by electromyographic activity of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia due to COVID-19 and the parameters of respiratory frequency and levels of acute hypoxemia measured by the SpO2/FiO2 ratio?
The rationale for this study is that the COVID-19 pandemic has caused significant impacts on global public health due to the high volume of respiratory complications in the face of a limited supply of healthcare resources, consequently leading to high mortality. Complications are initially manifested by acute hypoxemia associated with COVID-19 infection, sometimes silent upon visual inspection or using less sensitive methods. This complicates the management of compensatory respiratory work for hypoxemia, even with oxygen therapy support. Respiratory muscle recruitment involves aspects of inspiratory effort and ventilatory mechanics. Recognizing the presence and recruitment pattern of muscles involved in a timely manner can contribute to the clinical management success rate of individuals affected by respiratory dysfunction associated with COVID-19, especially at different levels of acute hypoxemia. Surface electromyography is a non-invasive, low-risk tool compatible with the analysis of respiratory muscle recruitment patterns. However, there are no studies describing this pattern in COVID-19 patients, serving as a basis for personalized therapeutic strategies.
1. Leading Question: How does the recruitment pattern of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia caused by COVID-19 behave when assessed through EMGs, considering the SpO2/FiO2 ratio as the analysis parameter?
2. Leading Question: Is there a relationship between the respiratory work estimated by electromyographic activity of diaphragmatic and extradiaphragmatic muscles in patients with acute hypoxemia due to COVID-19 and the parameters of respiratory frequency and levels of acute hypoxemia measured by the SpO2/FiO2 ratio?
The rationale for this study is that the COVID-19 pandemic has caused significant impacts on global public health due to the high volume of respiratory complications in the face of a limited supply of healthcare resources, consequently leading to high mortality. Complications are initially manifested by acute hypoxemia associated with COVID-19 infection, sometimes silent upon visual inspection or using less sensitive methods. This complicates the management of compensatory respiratory work for hypoxemia, even with oxygen therapy support. Respiratory muscle recruitment involves aspects of inspiratory effort and ventilatory mechanics. Recognizing the presence and recruitment pattern of muscles involved in a timely manner can contribute to the clinical management success rate of individuals affected by respiratory dysfunction associated with COVID-19, especially at different levels of acute hypoxemia. Surface electromyography is a non-invasive, low-risk tool compatible with the analysis of respiratory muscle recruitment patterns. However, there are no studies describing this pattern in COVID-19 patients, serving as a basis for personalized therapeutic strategies.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Respiratory Muscle Stretching Effect on Functional and Electromyographic Parameters of Patients With and Without COPD
NCT03417908
COPD
UNKNOWN
NA
Inspiratory Muscle Training in Post COVID-19 Infection Subjects
NCT05282199
COVID-19
COMPLETED
NA
Inspiratory Muscle Training in COVID-19 Patients
NCT04595097
Covid19
Exercise
COMPLETED
NA
Effects of Respiratory Muscle Training in Individuals With Long-term Post-COVID-19 Symptoms
NCT05597774
Covid19
Post-acute COVID-19 Syndrome
COMPLETED
NA
Efficacy of Home Inspiratory Muscle Training in Post-covid-19 Patients: a Randomized Clinical Trial
NCT05077241
Covid19
UNKNOWN
NA
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
1. GENERAL OBJECTIVE To analyze the clinical aspects of surface electromyography of respiratory muscles in COVID-19 patients under different levels of hypoxemia.
2. SPECIFIC OBJECTIVES To analyze the recruitment pattern of diaphragmatic and extradiaphragmatic muscles (sternocleidomastoid, scalene, and rectus abdominis) under different levels of acute hypoxemia in COVID-19 patients using the SpO2/FiO2 ratio as an analysis parameter and their relationships with clinical outcomes.
3. STUDY SITE AND PERIOD This study was conducted in the Intensive Care Unit in the Severe Acute Respiratory Syndrome (SARS) sector of Otávio de Freitas Hospital (HOF), located in the city of Recife, Pernambuco - Brazil.
4. SAMPLE The sample for this study consisted of spontaneously breathing patients admitted to the ICU diagnosed with COVID-19, who required low-flow oxygen therapy, using a nasal oxygen catheter or non-rebreathing mask.
5. CLINICAL EVALUATION At the beginning, a comprehensive clinical assessment was carried out which included the following parameters: name, assessment date, date of birth, address, telephone contact, age (years), sex (male/female), weight (kg), height (cm ), Body Mass Index (BMI - weight, kg / height², m²), Heart Rate (HR - bpm), Respiratory Rate (RR - rpm) assessed through chest expansibility (assessed visually for 1 minute), Systolic Blood Pressure (SBP - in mmHg), Diastolic Blood Pressure (DBP - in mmHg), Mean Arterial Pressure (MAP), Peripheral Oxygen Saturation (SpO2), method of administration in oxygen therapy, medications in use, other diagnoses, length of stay in the ICU , as well as outcomes of tracheal intubation and death were analyzed prospectively.
6. ASSESSMENT INSTRUMENTS Assessment of the severity of COVID-19 using the National Early Warning Score (NEWS2) and the Simplified Acute Physiological Score (SAPS3); Stratification of oxygenation status based on the relationship between blood oxygen saturation (SpO2) and the fraction of inspired oxygen (FiO2) SpO2/FiO2, divided into three categories: normal (\> 315), mild to moderate (314 - 235) and severe (\< 234); Assessment of the perception of respiratory effort using the modified Borg scale and assessment of respiratory work specific to COVID-19, which has been predicting the need for intubation; Evaluation of surface electromyography in the respiratory muscles, electrodes positioned in such a way that they aligned with the muscle fibers of the sternocleidomastoid, scalenes, diaphragm and rectus abdominis muscles.
7. RESULTS Independently of the severity of hypoxemia, the observed pattern of muscle recruitment remained similar between the groups, with higher RMS values for the extradiaphragmatic muscles (scalene and sternocleidomastoid), followed by the diaphragm and rectus abdominis muscles, respectively. When comparing the SpO2/FiO2 groups, significant differences were observed in the scalene and sternocleidomastoid muscles. The scalene muscles showed lower activation in mild-moderate and severe cases compared to the normal group, while the sternocleidomastoid also exhibited reduced activation in mild-moderate cases compared to the normal group. However, no differences were identified in the recruitment level of the diaphragm and rectus abdominis muscles among the SpO2/FiO2 groups.
8. ETHICAL ASPECTS This research project was approved by the Human Research Ethics Committee of the Federal University of Pernambuco (UFPE), where it complied with the postulates of the Declaration of Helsinki, following the terms recommended by the National Health Council (Resolution No. 466/ 2012) for research involving human subjects (approval number 4,560,383)
2. SPECIFIC OBJECTIVES To analyze the recruitment pattern of diaphragmatic and extradiaphragmatic muscles (sternocleidomastoid, scalene, and rectus abdominis) under different levels of acute hypoxemia in COVID-19 patients using the SpO2/FiO2 ratio as an analysis parameter and their relationships with clinical outcomes.
3. STUDY SITE AND PERIOD This study was conducted in the Intensive Care Unit in the Severe Acute Respiratory Syndrome (SARS) sector of Otávio de Freitas Hospital (HOF), located in the city of Recife, Pernambuco - Brazil.
4. SAMPLE The sample for this study consisted of spontaneously breathing patients admitted to the ICU diagnosed with COVID-19, who required low-flow oxygen therapy, using a nasal oxygen catheter or non-rebreathing mask.
5. CLINICAL EVALUATION At the beginning, a comprehensive clinical assessment was carried out which included the following parameters: name, assessment date, date of birth, address, telephone contact, age (years), sex (male/female), weight (kg), height (cm ), Body Mass Index (BMI - weight, kg / height², m²), Heart Rate (HR - bpm), Respiratory Rate (RR - rpm) assessed through chest expansibility (assessed visually for 1 minute), Systolic Blood Pressure (SBP - in mmHg), Diastolic Blood Pressure (DBP - in mmHg), Mean Arterial Pressure (MAP), Peripheral Oxygen Saturation (SpO2), method of administration in oxygen therapy, medications in use, other diagnoses, length of stay in the ICU , as well as outcomes of tracheal intubation and death were analyzed prospectively.
6. ASSESSMENT INSTRUMENTS Assessment of the severity of COVID-19 using the National Early Warning Score (NEWS2) and the Simplified Acute Physiological Score (SAPS3); Stratification of oxygenation status based on the relationship between blood oxygen saturation (SpO2) and the fraction of inspired oxygen (FiO2) SpO2/FiO2, divided into three categories: normal (\> 315), mild to moderate (314 - 235) and severe (\< 234); Assessment of the perception of respiratory effort using the modified Borg scale and assessment of respiratory work specific to COVID-19, which has been predicting the need for intubation; Evaluation of surface electromyography in the respiratory muscles, electrodes positioned in such a way that they aligned with the muscle fibers of the sternocleidomastoid, scalenes, diaphragm and rectus abdominis muscles.
7. RESULTS Independently of the severity of hypoxemia, the observed pattern of muscle recruitment remained similar between the groups, with higher RMS values for the extradiaphragmatic muscles (scalene and sternocleidomastoid), followed by the diaphragm and rectus abdominis muscles, respectively. When comparing the SpO2/FiO2 groups, significant differences were observed in the scalene and sternocleidomastoid muscles. The scalene muscles showed lower activation in mild-moderate and severe cases compared to the normal group, while the sternocleidomastoid also exhibited reduced activation in mild-moderate cases compared to the normal group. However, no differences were identified in the recruitment level of the diaphragm and rectus abdominis muscles among the SpO2/FiO2 groups.
8. ETHICAL ASPECTS This research project was approved by the Human Research Ethics Committee of the Federal University of Pernambuco (UFPE), where it complied with the postulates of the Declaration of Helsinki, following the terms recommended by the National Health Council (Resolution No. 466/ 2012) for research involving human subjects (approval number 4,560,383)
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
COVID-19 Respiratory Infection
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
OTHER
Study Time Perspective
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Classification of oxygenation status stratification
Patients were classified into 3 groups with stratification of oxygenation status based on the relationship between blood oxygen saturation (SpO2) and fraction of inspired oxygen (FiO2) SpO2/FiO2, divided into three categories: normal (\> 315), mild to moderate (314 - 235) and severe (\< 234).
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Both genders
* Age ≥ 18 years
* Confirmed diagnosis for COVID-19 considering its positivity through the RT-PCR test
* Patients who required low-flow oxygen therapy (nasal oxygen catheter or non-rebreathing mask)
* Hemodynamic stability (heart rate between 60 - 149 bpm, systolic blood pressure ≤149/89 mmHg or diastolic ≥ 90/60 mmHg at the time of collection)
* Body Mass Index ≤ 30 kg/m².
* Age ≥ 18 years
* Confirmed diagnosis for COVID-19 considering its positivity through the RT-PCR test
* Patients who required low-flow oxygen therapy (nasal oxygen catheter or non-rebreathing mask)
* Hemodynamic stability (heart rate between 60 - 149 bpm, systolic blood pressure ≤149/89 mmHg or diastolic ≥ 90/60 mmHg at the time of collection)
* Body Mass Index ≤ 30 kg/m².
Exclusion Criteria
* Anxiety and psychomotor agitation
* Postural deformities (hyperlordosis, hyperkyphosis, lateral inclinations and antalgic postures)
* Patients with chronic lung disease or diaphragmatic disorders
* Undergoing surgical procedures on the spine
* Neurological diseases that affect myoelectric conduction
* Trauma or musculoskeletal injuries to the rib cage or respiratory muscles
* Use of tracheostomy tubes
* History of use of invasive mechanical ventilation during hospitalization (diagnosed and previously described in the electronic medical record)
* Those who were using sedatives and bronchodilators, as well as a reduction in SpO2 during signal acquisition at the time of collection.
* Postural deformities (hyperlordosis, hyperkyphosis, lateral inclinations and antalgic postures)
* Patients with chronic lung disease or diaphragmatic disorders
* Undergoing surgical procedures on the spine
* Neurological diseases that affect myoelectric conduction
* Trauma or musculoskeletal injuries to the rib cage or respiratory muscles
* Use of tracheostomy tubes
* History of use of invasive mechanical ventilation during hospitalization (diagnosed and previously described in the electronic medical record)
* Those who were using sedatives and bronchodilators, as well as a reduction in SpO2 during signal acquisition at the time of collection.
Minimum Eligible Age
18 Years
Maximum Eligible Age
90 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Coordination for the Improvement of Higher Education Personnel
OTHER
Sponsor Role
collaborator
Conselho Nacional de Desenvolvimento Científico e Tecnológico
OTHER_GOV
Sponsor Role
collaborator
Fundação de Amparo à Ciência e Tecnologia de Pernambuco
OTHER
Sponsor Role
collaborator
University of Pernambuco
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Shirley Lima Campos
Associate Professor
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Emanuel Fernandes Ferreira da silva Júnior
Role: PRINCIPAL_INVESTIGATOR
Universidade Federal de Pernambuco
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Physical Therapy Department, Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Brazil
References
Explore related publications, articles, or registry entries linked to this study.
Miralles R, Gamboa NA, Gutierrez MF, Santander H, Valenzuela S, Bull R, Fuentes AD, Cordova R. Effect of breathing type on electromyographic activity of respiratory muscles during tooth clenching at different decubitus positions. Cranio. 2019 Jan;37(1):28-34. doi: 10.1080/08869634.2018.1470274. Epub 2018 May 7.
Reference Type
BACKGROUND
Alonso JF, Mananas MA, Rojas M, Bruce EN. Coordination of respiratory muscles assessed by means of nonlinear forecasting of demodulated myographic signals. J Electromyogr Kinesiol. 2011 Dec;21(6):1064-73. doi: 10.1016/j.jelekin.2011.07.004. Epub 2011 Aug 6.
Reference Type
RESULT
American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624. doi: 10.1164/rccm.166.4.518. No abstract available.
Reference Type
RESULT
Apigo M, Schechtman J, Dhliwayo N, Al Tameemi M, Gazmuri RJ. Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia. Crit Care. 2020 Jul 31;24(1):477. doi: 10.1186/s13054-020-03176-y. No abstract available.
Reference Type
RESULT
Beck J, Sinderby C, Lindstrom L, Grassino A. Diaphragm interference pattern EMG and compound muscle action potentials: effects of chest wall configuration. J Appl Physiol (1985). 1997 Feb;82(2):520-30. doi: 10.1152/jappl.1997.82.2.520.
Reference Type
RESULT
Bissett B, Gosselink R, van Haren FMP. Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach. Crit Care. 2020 Mar 24;24(1):103. doi: 10.1186/s13054-020-2783-0.
Reference Type
RESULT
Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.
Reference Type
RESULT
Cabanes-Martinez L, Villadoniga M, Gonzalez-Rodriguez L, Araque L, Diaz-Cid A, Ruz-Caracuel I, Pian H, Sanchez-Alonso S, Fanjul S, Del Alamo M, Regidor I. Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol. 2020 Dec;131(12):2809-2816. doi: 10.1016/j.clinph.2020.09.017. Epub 2020 Oct 15.
Reference Type
RESULT
Caruso P, Albuquerque AL, Santana PV, Cardenas LZ, Ferreira JG, Prina E, Trevizan PF, Pereira MC, Iamonti V, Pletsch R, Macchione MC, Carvalho CR. Diagnostic methods to assess inspiratory and expiratory muscle strength. J Bras Pneumol. 2015 Mar-Apr;41(2):110-23. doi: 10.1590/S1806-37132015000004474.
Reference Type
RESULT
Cecchini J, Schmidt M, Demoule A, Similowski T. Increased diaphragmatic contribution to inspiratory effort during neurally adjusted ventilatory assistance versus pressure support: an electromyographic study. Anesthesiology. 2014 Nov;121(5):1028-36. doi: 10.1097/ALN.0000000000000432.
Reference Type
RESULT
Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24.
Reference Type
RESULT
Chiti L, Biondi G, Morelot-Panzini C, Raux M, Similowski T, Hug F. Scalene muscle activity during progressive inspiratory loading under pressure support ventilation in normal humans. Respir Physiol Neurobiol. 2008 Dec 31;164(3):441-8. doi: 10.1016/j.resp.2008.09.010. Epub 2008 Oct 4.
Reference Type
RESULT
Palacios Cruz M, Santos E, Velazquez Cervantes MA, Leon Juarez M. COVID-19, a worldwide public health emergency. Rev Clin Esp. 2021 Jan;221(1):55-61. doi: 10.1016/j.rce.2020.03.001. Epub 2020 Mar 20. English, Spanish.
Reference Type
RESULT
Da Gama AE, de Andrade Carvalho L, Feitosa LA, do Nascimento Junior JF, da Silva MG, Amorim CF, Aliverti A, Lambertz D, Rodrigues MA, de Andrade AD. Acute effects of incremental inspiratory loads on compartmental chest wall volume and predominant activity frequency of inspiratory muscle. J Electromyogr Kinesiol. 2013 Dec;23(6):1269-77. doi: 10.1016/j.jelekin.2013.07.014. Epub 2013 Aug 11.
Reference Type
RESULT
Daimon S, Yamaguchi K. Changes in respiratory activity induced by mastication during oral breathing in humans. J Appl Physiol (1985). 2014 Jun 1;116(11):1365-70. doi: 10.1152/japplphysiol.01236.2013. Epub 2014 Apr 17.
Reference Type
RESULT
Dionne A, Parkes A, Engler B, Watson BV, Nicolle MW. Determination of the best electrode position for recording of the diaphragm compound muscle action potential. Muscle Nerve. 2009 Jul;40(1):37-41. doi: 10.1002/mus.21290.
Reference Type
RESULT
Dos Reis IMM, Ohara DG, Januario LB, Basso-Vanelli RP, Oliveira AB, Jamami M. Surface electromyography in inspiratory muscles in adults and elderly individuals: A systematic review. J Electromyogr Kinesiol. 2019 Feb;44:139-155. doi: 10.1016/j.jelekin.2019.01.002. Epub 2019 Jan 11.
Reference Type
RESULT
Drake JD, Callaghan JP. Elimination of electrocardiogram contamination from electromyogram signals: An evaluation of currently used removal techniques. J Electromyogr Kinesiol. 2006 Apr;16(2):175-87. doi: 10.1016/j.jelekin.2005.07.003. Epub 2005 Aug 31.
Reference Type
RESULT
Dres M, Schmidt M, Ferre A, Mayaux J, Similowski T, Demoule A. Diaphragm electromyographic activity as a predictor of weaning failure. Intensive Care Med. 2012 Dec;38(12):2017-25. doi: 10.1007/s00134-012-2700-3. Epub 2012 Sep 26.
Reference Type
RESULT
Duiverman ML, de Boer EW, van Eykern LA, de Greef MH, Jansen DF, Wempe JB, Kerstjens HA, Wijkstra PJ. Respiratory muscle activity and dyspnea during exercise in chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2009 Jun 30;167(2):195-200. doi: 10.1016/j.resp.2009.04.018. Epub 2009 May 3.
Reference Type
RESULT
Falla D, Dall'Alba P, Rainoldi A, Merletti R, Jull G. Location of innervation zones of sternocleidomastoid and scalene muscles--a basis for clinical and research electromyography applications. Clin Neurophysiol. 2002 Jan;113(1):57-63. doi: 10.1016/s1388-2457(01)00708-8.
Reference Type
RESULT
Gallego J, Perez de la Sota A, Vardon G, Jaeger-Denavit O. Electromyographic feedback for learning to activate thoracic inspiratory muscles. Am J Phys Med Rehabil. 1991 Aug;70(4):186-90. doi: 10.1097/00002060-199108000-00005.
Reference Type
RESULT
Hermens HJ, Freriks B, Disselhorst-Klug C, Rau G. Development of recommendations for SEMG sensors and sensor placement procedures. J Electromyogr Kinesiol. 2000 Oct;10(5):361-74. doi: 10.1016/s1050-6411(00)00027-4.
Reference Type
RESULT
Hutten GJ, van Thuijl HF, van Bellegem AC, van Eykern LA, van Aalderen WM. A literature review of the methodology of EMG recordings of the diaphragm. J Electromyogr Kinesiol. 2010 Apr;20(2):185-90. doi: 10.1016/j.jelekin.2009.02.008. Epub 2009 May 6.
Reference Type
RESULT
Segizbaeva MO, Aleksandrova NP. [Inspiratory muscle resistance to fatigue during exercise and simulated airway obstruction]. Fiziol Cheloveka. 2014 Nov-Dec;40(6):114-22. Russian.
Reference Type
RESULT
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Dec;588(7836):E6. doi: 10.1038/s41586-020-2951-z. No abstract available.
Reference Type
RESULT
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
42130821.9.3001.5200
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Effects of Unsupervised Inspiratory Muscle Training on Ventilation Variability in Post-covid-19 Patients.
NCT06362499
RECRUITING
NA
Acute Effects of Inspiratory Muscle Training on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients
NCT06827379
ENROLLING_BY_INVITATION
NA
Inspiratory Muscle Training and Neuromuscular Electrical Stimulation in Chronic Obstructive Pulmonary Disease
NCT04387318
COMPLETED
NA
Effectiveness of Inspiratory Muscle Training on Sleep in Patients With Obstructive Sleep Apnea
NCT07149233
ENROLLING_BY_INVITATION
NA
Inspiratory Muscle Training in Patients With COVID-19
NCT04603963
TERMINATED
NA
Effects of Respiratory Muscle Training in People Who Have Had COVID-19 Disease
NCT04734561
COMPLETED
NA
Effects of Inspiratory Muscle Training in Patients With Post COVID-19
NCT05231395
COMPLETED
NA
Effects of Respiratory Muscle Training and Respiratory Exercise in Exercise Tolerance, Performing Daily Life Activities and Quality of Life of Patients With Chronic Obstructive Pulmonary Disease
NCT01510041
UNKNOWN
NA
The Inspiratory Muscle Training Improves the Severity of Obstructive Sleep Apnea and Sleep Quality?
NCT02963844
COMPLETED
NA
Respiratory Muscle Assesment in COVID-patients Without Hospitalization
NCT06105450
COMPLETED
Home-based Exercise in COVID-19 Survivors
NCT04615052
UNKNOWN
NA
Intensity, Specificity and Reversibility of Inspiratory Muscle Training in Asthmatics
NCT02917824
COMPLETED
NA
Clinical Safety for the Inspiratory Muscle Training
NCT01952002
COMPLETED
Effects of Inspiratory Muscle Training After Covid-19 (ReCOV)
NCT05024474
COMPLETED
NA
Respiratory Muscles After Hospitalisation for COVID-19
NCT04854863
COMPLETED
Low-intensity Aerobic Training Associated With Global Muscle Strengthening in Post-COVID-19
NCT06161740
COMPLETED
NA
Inspiratory Muscle Training in Patients With Interstitial Lung Disease
NCT04481074
COMPLETED
NA
Activity of Inspiratory Muscles With the Use of Positive Pressure in Patients With Chronic Obstructive Pulmonary Disease
NCT01111487
COMPLETED
NA
Chest Wall Kinematics and Respiratory Muscle Action During Supine Breathing in Individuals With and Without Spinal Cord Injury
NCT01084512
COMPLETED
Respiratory Muscles After Inspiratory Muscle Training After COVID-19
NCT05582642
COMPLETED
NA
Inspiratory Muscle Training in Individuals With Cystic Fibrosis
NCT03737630
COMPLETED
NA
Inspiratory Muscle Training and Respiratory Electromyographic Activity in COPD
NCT02014155
COMPLETED
NA
Effect of Neuromuscular Electrical Stimulation of Lower Limbs on Improving Exercise Self-Efficacy, Dyspnea During Activity and Fatigue in Patients With Chronic Obstructive Pulmonary Disease
NCT06851195
ENROLLING_BY_INVITATION
NA
EFFECTS OF INSPIRATORY MUSCLE TRAINING IN POST-COVID-19 PATIENTS
NCT05493410
COMPLETED
NA