Effects of Respiratory Muscle Training in People Who Have Had COVID-19 Disease

NCT ID: NCT04734561

Last Updated: 2021-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-08

Study Completion Date

2021-09-29

Brief Summary

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The main objective of the present study is to observe the short-term effects of respiratory muscle training applied by telerehabilitation on quality of life and exercise tolerance in people who have had the COVID-19 disease. As secondary objectives, the effects on respiratory muscles strength/tolerance, pulmonary function and psychological and cognitive factors.

Detailed Description

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It is a double-blind randomized clinical trial study. Each participant will be randomly assigned to one of the following groups: 1) Inspiratory muscle training, 2) Placebo Inspiratory muscle training, 3) Inspiratory muscle training + Expiratory muscle training, 4) Placebo Inspiratory muscle training + Expiratory muscle training.

Each exercise training program will be applied twice per day 7 sessions per week during 8 weeks by a threshold device. The evening sessions will be supervised by a physiotherapist through a virtual platform.

Participants received baseline assessments at the beginning of the intervention, at the end of the 4th week, and post-intervention assessments at the end of the 8th week.

Conditions

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Covid19 Respiratory Muscle Training Respiratory Function Test Quality of Life Psychosocial Factor

Keywords

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COVID-19 Respiratory Muscle Training Respiratory Function Test Quality of Life Psychosocial Factor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

double-blind randomized controlled clinical trial
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Inspiratory muscle training group

Participants will perform an inspiratory muscle training by a threshold device at home, twice a day for 8 weeks supervised by a physiotherapist through a virtual platform.

Group Type EXPERIMENTAL

Inspiratory muscle training group

Intervention Type OTHER

Participants will perform an inspiratory muscle training including warm-up, recovery between intervals and return to calm.

Inspiratory muscle training placebo group

Participants will perform an inspiratory muscle training by a placebo threshold device at home, twice a day for 8 weeks supervised by a physiotherapist through a virtual platform.

Group Type SHAM_COMPARATOR

Inspiratory muscle training placebo group

Intervention Type OTHER

Participants will perform an inspiratory muscle training including warm-up, recovery between intervals and return to calm.

Inspiratory + expiratory muscle training group

Participants will perform an inspiratory and expiratory muscle training by a threshold device at home, twice a day for 8 weeks supervised by a physiotherapist through a virtual platform.

Group Type EXPERIMENTAL

Inspiratory + expiratory muscle training group

Intervention Type OTHER

Participants will perform an inspiratory and expiratory muscle training including warm-up, recovery between intervals and return to calm.

Inspiratory + expiratory muscle training placebo group

Participants will perform an inspiratory and expiratory muscle training by a placebo threshold device at home, twice a day for 8 weeks supervised by a physiotherapist through a virtual platform.

Group Type SHAM_COMPARATOR

Inspiratory + expiratory muscle training placebo group

Intervention Type OTHER

Participants will perform an inspiratory and expiratory muscle training including warm-up, recovery between intervals and return to calm.

Interventions

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Inspiratory muscle training group

Participants will perform an inspiratory muscle training including warm-up, recovery between intervals and return to calm.

Intervention Type OTHER

Inspiratory muscle training placebo group

Participants will perform an inspiratory muscle training including warm-up, recovery between intervals and return to calm.

Intervention Type OTHER

Inspiratory + expiratory muscle training group

Participants will perform an inspiratory and expiratory muscle training including warm-up, recovery between intervals and return to calm.

Intervention Type OTHER

Inspiratory + expiratory muscle training placebo group

Participants will perform an inspiratory and expiratory muscle training including warm-up, recovery between intervals and return to calm.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Positive diagnosis of COVID-19 (SARS-CoV2)
* Hospital admission for COVID-19 in the last 3 months
* Stable phase and home discharge;

Exclusion Criteria

* Severe cognitive impairment
* Any type of musculoskeletal, neurological, cardiac or respiratory disease where training is contraindicated
* Inability to carry out the training program through telematic supervision.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Colegio Profesional de Fisioterapeutas de la Comunidad de Madrid, Madrid, Spain

UNKNOWN

Sponsor Role collaborator

Universidad Complutense de Madrid

OTHER

Sponsor Role lead

Responsible Party

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Ibai López de Uralde Villanueva

Professor Ibai López de Uralde Villanueva

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ibai López de Uralde Villanueva, PhD

Role: PRINCIPAL_INVESTIGATOR

Universidad Complutense de Madrid

Locations

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UComplutenseMadrid

Madrid, , Spain

Site Status

Countries

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Spain

References

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Disser NP, De Micheli AJ, Schonk MM, Konnaris MA, Piacentini AN, Edon DL, Toresdahl BG, Rodeo SA, Casey EK, Mendias CL. Musculoskeletal Consequences of COVID-19. J Bone Joint Surg Am. 2020 Jul 15;102(14):1197-1204. doi: 10.2106/JBJS.20.00847.

Reference Type BACKGROUND
PMID: 32675661 (View on PubMed)

Barker-Davies RM, O'Sullivan O, Senaratne KPP, Baker P, Cranley M, Dharm-Datta S, Ellis H, Goodall D, Gough M, Lewis S, Norman J, Papadopoulou T, Roscoe D, Sherwood D, Turner P, Walker T, Mistlin A, Phillip R, Nicol AM, Bennett AN, Bahadur S. The Stanford Hall consensus statement for post-COVID-19 rehabilitation. Br J Sports Med. 2020 Aug;54(16):949-959. doi: 10.1136/bjsports-2020-102596. Epub 2020 May 31.

Reference Type BACKGROUND
PMID: 32475821 (View on PubMed)

Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: interim guidance on rehabilitation in the hospital and post-hospital phase from a European Respiratory Society- and American Thoracic Society-coordinated international task force. Eur Respir J. 2020 Dec 3;56(6):2002197. doi: 10.1183/13993003.02197-2020. Print 2020 Dec.

Reference Type BACKGROUND
PMID: 32817258 (View on PubMed)

Jimenez-Pavon D, Carbonell-Baeza A, Lavie CJ. Physical exercise as therapy to fight against the mental and physical consequences of COVID-19 quarantine: Special focus in older people. Prog Cardiovasc Dis. 2020 May-Jun;63(3):386-388. doi: 10.1016/j.pcad.2020.03.009. Epub 2020 Mar 24. No abstract available.

Reference Type BACKGROUND
PMID: 32220590 (View on PubMed)

Liu K, Zhang W, Yang Y, Zhang J, Li Y, Chen Y. Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study. Complement Ther Clin Pract. 2020 May;39:101166. doi: 10.1016/j.ctcp.2020.101166. Epub 2020 Apr 1.

Reference Type BACKGROUND
PMID: 32379637 (View on PubMed)

Other Identifiers

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20/715-E_BS

Identifier Type: -

Identifier Source: org_study_id