Pilot Study of Stomach Cancer Early Detection and Prevention With Endoscopy

NCT ID: NCT05566899

Last Updated: 2023-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-08

Study Completion Date

2024-08-01

Brief Summary

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Screening esophagogastroduodenoscopy (EGD )provides three distinct opportunities to decrease gastric cancer (GC) morbidity and mortality. has potential to discover cancer in early stages before the onset of symptoms, leading to higher rates of survival. Second, premalignant lesions such as adenomatous polyps, intestinal metaplasia and dysplasia can be discovered and removed with local resection, akin to polypectomies during screening colonoscopies, preventing the development of cancer. Third, EGD discovery and treatment of active Helicobacter pylori (HP) infection of the stomach provides an opportunity for primary prevention of GC.

Detailed Description

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The primary objective of the study is to evaluate the acceptability and feasibility of EGD-SC.

The secondary objectives are:

1. Estimate Median added time needed for EGD at the time of routine screening colonoscopy
2. Estimate the frequencies of adverse events
3. Estimate the percentage of pre-cancer and cancerous lesions including H. pylori infection, chronic atrophic gastritis, IM, dysplasia and GC among this high GC risk population
4. Investigate whether high-risk racial/ethnicity groups have different likelihood of uptake of EGD, and whether the likelihood is associated with patient beliefs, attitudes and knowledge of GC, perceptions of risk, motivators and barriers, and sociocultural factors, as well as patient preference and satisfaction with EGD-SC

Conditions

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Gastric Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

A single-center, open label pilot study that will evaluate the acceptability and feasibility of EGD at time of routine screening colonoscopy (EGD-SC). The Pre-Study Screening is day -30 to day 0; EDG at time of routine screening colonoscopy and follow-up day five to seven.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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EGD at time of routine screening colonoscopy

This happens on Day 0. Screening for EGD, biopsy samples from esophagus, stomach, gastrointestinal junction, and duodenum AE's.

Group Type EXPERIMENTAL

esophagogastroduodenoscopy (EGD)

Intervention Type PROCEDURE

After colonoscopy, the patient will undergo the EGD at which time biopsy specimens will be obtained.

Participants will also be provided with a home stool collection kit which they can bring to the endoscopy visit or mail back. Satisfaction questions will be administered 3-7 days after EGD-SC

Interventions

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esophagogastroduodenoscopy (EGD)

After colonoscopy, the patient will undergo the EGD at which time biopsy specimens will be obtained.

Participants will also be provided with a home stool collection kit which they can bring to the endoscopy visit or mail back. Satisfaction questions will be administered 3-7 days after EGD-SC

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Have provided signed informed consent for the trial
* Aged =40 and =80 years at the time of informed consent
* Not planned to undergo EGD and not had EGD in the last five years
* Planned to undergo colonoscopy
* Half of the recruited subjects will be from high-risk groups
* Willing and able to comply with all aspects of the protocol

Exclusion Criteria

* Persons with total gastrectomy
* Persons with anatomic alteration that precludes EGD
* Medical conditions that substantially increase risks for EGD
* Had EGD in the last five years
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Haejin In

Surgical Oncology Associate Professor of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Haejin In, MD

Role: PRINCIPAL_INVESTIGATOR

Rutgers Cancer Institute of New Jersey

Locations

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Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Site Status RECRUITING

RWJBarnabas Health

New Brunswick, New Jersey, United States

Site Status NOT_YET_RECRUITING

Countries

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United States

Central Contacts

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Haejin In, MD

Role: CONTACT

732-235-3972

Facility Contacts

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Haejin In, MD

Role: primary

732-235-3972

Haejin In, MD

Role: primary

732-235-3972

Other Identifiers

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Pro2022001252

Identifier Type: OTHER

Identifier Source: secondary_id

072211

Identifier Type: -

Identifier Source: org_study_id

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