Intense Regulated Pulse Light Therapy in Dry Eye Disease
NCT ID: NCT05553561
Last Updated: 2023-02-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
34 participants
INTERVENTIONAL
2023-01-01
2023-12-31
Brief Summary
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Detailed Description
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Intense pulsed light (IPL) therapy is a new treatment strategy for treatment of MGD by inducing the restoration of the normal activity of the meibomian glands. In fact, IPL has been used for treating the patients with facial telangiectasias and erythema of rosacea and also resulted in improvement in ocular surface health.
Evaporative form is the commonest form of DED and it is mainly caused by meibomian glands dysfunction (MGD). The usual traditional treatment options for MGD include warm compresses, expression of meibomian glands (MG), anti-inflammatory drugs, and lubricant eye drops.
The aim of this study is to assess the effect of intense regulated pulse light (IRPL) on the treatment of Dry eye.
The study included 34 patients with moderate to severe evaporative dry eye. The symptoms will be assessed with the Dry Eye-Related Quality of Life Score (DEQ-5) Questionnaire. The tear film will be assessed through MediWorks D130+S390L (WDR) which is a device attached to the slit lamp for non-invasive examination of tear film.
Patients will be divided into 2 groups: The 1st group include (17) patients who will be treated with Intense Regulated Pulse Light (IRPL) \& the 2nd group include (17) patients will treated by traditional methods of MGD as Eyelid hygiene, topical lubricant, topical \& systemic antibiotics \& anti-inflammatory agents
IRPL will be done using E-Eye (E-Swin, France) \& each patient will undergo 3 sessions on Day (1), Day (15), and Day (45).
The patients will be reassessed after the 3rd session.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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IRPL Therapy
17 patients with moderate to severe evaporative dry eye disease will treated with 3 sessions of IRPL therapy.
IPRL device
Intense pulsed light therapy (IPL) is a non-coherent large wavelength high-intensity light in the range of 500-1200nm. It has been used by many investigators for the treatment of evaporative dry eye safely and effectively.
Non IRPL Therapy
17 patients with moderate to severe evaporative dry eye disease will treated with traditional methods of MGD
pharmacological therapy & Eyelid hygiene
traditional methods of MGD treatment as Eyelid hygiene, topical preservative free lubricant, topical \& systemic antibiotics \& anti-inflammatory agent
Interventions
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IPRL device
Intense pulsed light therapy (IPL) is a non-coherent large wavelength high-intensity light in the range of 500-1200nm. It has been used by many investigators for the treatment of evaporative dry eye safely and effectively.
pharmacological therapy & Eyelid hygiene
traditional methods of MGD treatment as Eyelid hygiene, topical preservative free lubricant, topical \& systemic antibiotics \& anti-inflammatory agent
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnancy.
* Ocular surgery or dermatologic treatments in the previous Two months or during the treatment period.
* Implants, tattoos, or pigmented lesions in the treatment area.
* Contraindications to IPL therapy, including the use of photosensitive medications.
18 Years
75 Years
ALL
No
Sponsors
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Menoufia University
OTHER
Responsible Party
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Rofaida Mostafa Mansour Serag EL Deen
Ophthalmologist at Menoufia university hospitals
Locations
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Monoufia university
Menoufia, , Egypt
Countries
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Central Contacts
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Other Identifiers
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7/2022OPHT23
Identifier Type: -
Identifier Source: org_study_id
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