Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial
NCT ID: NCT06745089
Last Updated: 2024-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
45 participants
INTERVENTIONAL
2022-07-13
2024-03-10
Brief Summary
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The main questions it aims to answer are:
* What subtype of meibomian gland dysfunction (MGD) better responds to which treatment modality?
* How long do the treatment effects last?
Researchers will compare each group (IPL and TPT) to a control group treated with eyedrops.
\* Do combined treatment of IPL or TPT with eyedrops show better outcomes than only eyedrops?
Participants will:
* Receive different treatment for 2 months according to the group they were randomly allocated to.
* Visit the clinic for checkups after 1 and 3 months after completing the treatment sessions.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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IPL arm
Intense pulsed light
Intense pulsed light exerts photothermal, photochemical effects, and photobiomodulation on meibomian glands.
TPT arm
thermal pulsation therapy
Thermal pulsation therapy utilizes local heating and massage on the eyelids.
Control arm
Ocular lubricant
Ocular lubricants moisturize the ocular surface.
Interventions
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Intense pulsed light
Intense pulsed light exerts photothermal, photochemical effects, and photobiomodulation on meibomian glands.
thermal pulsation therapy
Thermal pulsation therapy utilizes local heating and massage on the eyelids.
Ocular lubricant
Ocular lubricants moisturize the ocular surface.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* ocular infection
* eyelid abnormalities (e.g., entropion, ectropion, lagophthalmos, severe ptosis or trichiasis)
* blepharospasm
* eyelid tumor
* severe meibomian gland atrophy
* allergic to topical anesthetics
* sunbathe in recent one month
* periocular fillers
20 Years
75 Years
ALL
No
Sponsors
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Nobel Eye Institute
UNKNOWN
National Science and Technology Council, Taiwan
OTHER_GOV
National Health Research Institutes, Taiwan
OTHER
National Yang Ming Chiao Tung University
OTHER
Responsible Party
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Wen-Chuan Kuo
Professor and Director, Institute of Biophotonics, National Yang Ming Chiao Tung University
Locations
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Institute of Biophotonics, National Yang Ming Chiao Tung University
Taipei, , Taiwan
Countries
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Other Identifiers
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IRB number: YM111073F
Identifier Type: -
Identifier Source: org_study_id