Drug Wastage : Observational Study in Intensive Care Units in France
NCT ID: NCT05553054
Last Updated: 2026-01-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1066 participants
OBSERVATIONAL
2022-11-08
2023-03-15
Brief Summary
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Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice, this is not systematic. Moreover, data on drug wastage in Intensive Care Units (ICU) are rare.
GAME-OVER observational study aims to evaluate drug wastage in ICU in France and to suggest ways to improve health care practices.
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Detailed Description
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Collection starts when day shift starts (at 7:00 am) and ends when night shift leaves (at 7:00 am the following day).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Intravenous (IV) drugs
Patient and prepared/administrated/discarded IV drugs data will be collected during 24 hours.
Quantification of IV drugs wastage
Drugs are prescribed depending on physician discretion.
Specific collection bins are provided to ICU. Healthcare teams discard syringes labelled with name and dilution which have been used to prepare drugs into these bins. After 24 hours of collection, bins are analyzed by investigators.
Interventions
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Quantification of IV drugs wastage
Drugs are prescribed depending on physician discretion.
Specific collection bins are provided to ICU. Healthcare teams discard syringes labelled with name and dilution which have been used to prepare drugs into these bins. After 24 hours of collection, bins are analyzed by investigators.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Sainte-Anne Military Teaching Hospital
UNKNOWN
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
OTHER
Responsible Party
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Principal Investigators
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Erwan D'ARANDA, MD
Role: STUDY_DIRECTOR
Sainte-Anne Military Teaching Hospital
Locations
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Centre Hospitalier de Charleville-Mezieres
Charleville-Mézières, Ardennes, France
CHRU de Strasbourg
Strasbourg, Bas-Rhin, France
Hôpital Nord
Marseille, Bouches Du Rhône, France
Centre Hospitalier d'Aurillac
Aurillac, Cantal, France
Groupe Hospitalier Littoral Atlantique
La Rochelle, Charente-Maritime, France
CHU de Besançon
Besançon, Doubs, France
Centre Hospitalier de Montélimar
Montélimar, Drôme, France
Hôpital privé Claude Galien
Quincy-sous-Sénart, Essonne, France
HIA Clermont Tonnerre
Brest, Finistère, France
CHRU de Brest
Brest, Finistère, France
CHU de Nîmes
Nîmes, Gard, France
Clinique Saint Augustin
Bordeaux, Gironde, France
CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, Gironde, France
HIA Robert Picqué
Bordeaux, Gironde, France
Hôpital Robert Boulin
Libourne, Gironde, France
CHU de Toulouse - Hôpital Purpan
Toulouse, Haute Garonne, France
Clinique la Croix du Sud
Quint-Fonsegrives, Haute-Garonne, France
CHU de Toulouse - Hôpital Rangueil
Toulouse, Haute-Garonne, France
Clinique Pasteur
Toulouse, Haute-Garonne, France
Centre Hospitalier Emile Roux
Le Puy-en-Velay, Haute-Loire, France
Hôpital privé d'Antony
Antony, Hauts-de-Seine, France
HIA Percy-Clamart
Clamart, Hauts-de-Seine, France
Hôpital Américain de Paris
Neuilly-sur-Seine, Hauts-de-Seine, France
CHU de Rennes
Rennes, Ille-et-Vilaine, France
CHRU de Tours
Chambray-lès-Tours, Indre-et-Loire, France
CHU de Grenoble
La Tronche, Isère, France
Centre Hospitalier de Dax
Dax, Landes, France
Centre Hospitalier de Mont-de-Marsan
Mont-de-Marsan, Landes, France
Centre Hospitalier Simone Veil
Blois, Loir-et-Cher, France
Centre Hospitalier de Saint Nazaire
Saint-Nazaire, Loire-Atlantique, France
Centre Hospitalier d'Orléans
Orléans, Loiret, France
Centre Hospitalier de Cahors
Cahors, Lot, France
CHU d'Angers
Angers, Maine-et-Loire, France
Centre Hospitalier Mémorial de Saint-Lô
Saint-Lô, Manche, France
CHU de Reims
Reims, Marne, France
Centre Hospitalier Bretagne Atlantique de Vannes
Vannes, Morbihan, France
CHU de Lille - Hôpital Huriez
Lille, Nord, France
CHU de Lille - Hôpital Roger Salengro
Lille, Nord, France
Centre Hospitalier du Forez
Montbrison, Pays de la Loire Region, France
CHU de Saint-Etienne
Saint-Priest-en-Jarez, Pays de la Loire Region, France
CHU de Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dôme, France
Hôpital Pierre Wertheimer
Bron, Rhône, France
Hôpital Edouard Herriot
Lyon, Rhône, France
Clinique de la Sauvegarde
Lyon, Rhône, France
CHU Félix-Guyon
Saint-Denis, Réunion, France
CHU de la Réunion
Saint-Pierre, Réunion, France
Grand Hôpital de l'Est Francilien
Meaux, Seine-et-Marne, France
CHU d'Amiens
Amiens, Somme, France
Hôpital Nord Franche-Comté
Trévenans, Territoire De Belfort, France
Centre Hospitalier Victor Dupouy
Argenteuil, Val d'Oise, France
Hôpital Henri Mondor
Créteil, Val-de-Marne, France
HIA Sainte Anne
Toulon, Var, France
Hôpital Sainte Musse
Toulon, Var, France
CHU de Poitiers
Poitiers, Vienne, France
Centre Hospitalier de Versailles
Le Chesnay, Yvelines, France
CHU Dupuytren
Limoges, , France
Hôpital Lariboisière
Paris, , France
Hôpital La Pitié-Salpétrière
Paris, , France
Hôpital Bichat
Paris, , France
Centre Hospitalier de Mayotte
Mamoudzou, , Mayotte
Centre Hospitalier Princesse Grace
Monaco, , Monaco
Countries
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References
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d'Aranda E, Pons S, Chelly J, Atchade E, Bonnet L; SFAR Sustainable Development Committee; Dahyot-Fizelier C; SFAR Critical Care Committee; Kamel T, Giannoni F, Collange O, Besnier E, Schoeffler M, Mayeur N, Quere PL, Marecal L, Pernod C, Geay C, Esnault P, Cinotti R; SFAR Research Network; Cesana M, Cungi PJ. Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study. Crit Care. 2025 Feb 21;29(1):84. doi: 10.1186/s13054-025-05299-6.
Atchade E, Cungi PJ, Pons S, Dahyot-Fizelier C, Cesana M, Lukaszewicz AC, Bouhemad B, Trouiller P, Chelly J, Montravers P, Vardon F, D'Aranda E; SFAR Critical Care Committee; SFAR Sustainability Committee; SFAR Research Network; GAME-OVER Study group; GAME-OVER investigators group. Characteristics of French intensive care units and patients: an ancillary analysis of the GAME-OVER study. BMC Anesthesiol. 2025 Dec 5. doi: 10.1186/s12871-025-03473-5. Online ahead of print. No abstract available.
d'Aranda E, Cungi PJ, Chelly J, Pons S; GAME-OVER Study Group, GAME-OVER Study Investigators, French Society of Anesthesia & Intensive Care Medicine (SFAR) Sustainability; Committee, SFAR Critical Care Committee, and SFAR Research Network; GAME-OVER Study Group, GAME-OVER Study Investigators, French Society of Anesthesia & Intensive Care Medicine (SFAR) Sustainability and Committee, SFAR Critical Care Committee, and SFAR Research Network. Sustainable Intensive Care: Do Not Forget IV to Oral Switch! Crit Care Med. 2026 Jan 1;54(1):218-223. doi: 10.1097/CCM.0000000000006944. Epub 2026 Jan 6. No abstract available.
Other Identifiers
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2022-CHITS-009
Identifier Type: -
Identifier Source: org_study_id
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