Regeneron AA Multicenter (Dupilumab)

NCT ID: NCT05551793

Last Updated: 2025-07-29

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 68 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-04-10
• Study Completion Date: 2027-11-03

Brief Summary

This is a prospective, randomized, double blind, placebo-controlled clinical trial. The study will take place at 4 sites. This trial will enroll a total of 68 patients with moderate to severe AA (affecting more than 50% of the scalp) at the time of screening with a targeted 54 subjects completers through Week 48. AA subjects must have evidence of hair regrowth within the last 7 years of their last episode of hair loss; and have screening IgE ≥ 200 and/or have personal and/or familial history of atopy.

Subjects will be randomized (2:1) to either receive weekly dupilumab or placebo for 48 weeks, with all subjects completing participation through Week 48 receiving an additional 48 weeks of dupilumab (through Week 96).

Conditions

Alopecia Areata

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Dupilumab

Dupilumab: weekly 300mg SC injections Manufacturer: Regeneron

Group Type: EXPERIMENTAL

Dupilumab

Intervention Type: DRUG

Dupilumab: 300mg SC injections

Placebo

Placebo: weekly SC injections of equivalent volume Manufacturer: Regeneron

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Placebo: SC injections of equivalent volume

Interventions

Dupilumab

Dupilumab: 300mg SC injections

Intervention Type: DRUG

Placebo

Placebo: SC injections of equivalent volume

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Male or female subjects who are at least 18 years old at the time of informed consent.
• Subject is able to understand and voluntarily sign an informed consent document prior to participation in any study assessments or procedures.
• Subject is able to adhere to the study visit schedule and other protocol requirements.
• Females of childbearing potential (FCBP) must have a negative pregnancy test at Screening and Baseline. While on investigational product and for at least 28 days after taking the last dose of investigational product (IP), FCBP who engage in activity in which conception is possible must use one of the approved contraceptive options described below:

• Option 1: Any one of the following highly effective methods: hormonal contraception (oral, injection, implant, transdermal patch, vaginal ring); intrauterine device (IUD); tubal ligation; or partner's vasectomy, OR;
• Option 2: Male or female condom (latex condom or non-latex condom NOT made out of natural [animal] membrane [for example, polyurethane]); PLUS one additional barrier method: (a) diaphragm with spermicide; (b) cervical cap with spermicide; or (c) contraceptive sponge with spermicide.
• If subject is a female of non-childbearing potential, she must have documented history of infertility, be in a menopausal state for one year, or had a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy.
• Subject has a history of at least 6 months of moderate to severe AA (≥ 50% scalp involvement) as measured using the SALT score; OR subject has ≥ 95% loss of scalp hair for enrollment as AA totalis (AT) or universalis (AU) subtypes.
• Subject has a screening IgE > 200 and/or personal and/or familial history of atopy.
• Subjects must meet the following laboratory criteria:

• White blood cell count ≥ 3000/mm3 (≥ 3.0 x 109/L) and < 14,000/mm3 (≤ 14 x 109/L).
• Platelet count ≥ 100,000/μL (≥ 100 x 109/L).
• Serum creatinine ≤ 1.5 mg/dL (≤ 132.6 μmol/L).
• AST (SGOT) and ALT (SGPT) ≤ 2 x upper limit of normal (ULN). If the initial test shows ALT or AST > 2 times the ULN, one repeat test is allowed during the Screening Phase.
• Total bilirubin ≤ 2 mg/dL (34 μmol/L). If the initial test shows total bilirubin > 2 mg/dL (34 μmol/L), one repeat test is allowed during the Screening Phase.
• Hemoglobin ≥ 10 g/dL (≥ 6.2 mmol/L).
• Subject is judged to be in otherwise good overall health following a detailed medical and medication history, physical examination, and laboratory testing.

Exclusion Criteria

The presence of any of the following will exclude a subject from enrollment:

• Subject is pregnant or breastfeeding.
• Subject's cause of hair loss is indeterminable and/or they have concomitant causes of alopecia, such traction, cicatricial, pregnancy-related, drug-induced, telogen effluvium, or advanced androgenetic alopecia (i.e. Ludwig Type III or Norwood-Hamilton Stage ≥ V).
• Subject has a history of AA with no evidence of hair regrowth for ≥ 7 years since their last episode of hair loss.
• Severe, uncontrolled asthma or a history of life-threatening asthma exacerbations while on appropriate anti-asthmatic mediations.
• Subject has an active bacterial, viral, or helminth parasitic infections; OR a history of ongoing, recurrent severe infections requiring systemic antibiotics
• Subject with a known or suspected underlying immunodeficiency or immune-compromised state as determined by the investigator.
• Subject has a concurrent or recent history of severe, progressive, or uncontrolled renal, hepatic, hematological, intestinal, metabolic, endocrine, pulmonary, cardiovascular, or neurological disease.
• Active hepatitis B, hepatitis C, human immunodeficiency virus (HIV), or positive HIV serology or active or untreated latent tuberculosis at the time of screening for subjects determined by the investigators to be at high-risk for this disease.
• Subject has a suspected or active lymphoproliferative disorder or malignancy; OR a history of malignancy within 5 years before the Baseline assessment, except for completely treated in situ non-melanoma skin and cervical cancers without evidence of metastasis.
• Subject has received a live attenuated vaccine ≤ 30 days prior to study randomization.
• Subject has any uncertain or clinically significant laboratory abnormalities that may affect interpretation of study data or endpoints.
• Subject has any other medical or psychological condition that, in the opinion of the investigator, may present additional unreasonable risks as a result of their participation in the study and/or interfere with clinic visits and necessary study assessments.
• History of adverse systemic or allergic reactions to any component of the study drug.
• Severe, untreated asthma or a history of life-threatening asthma exacerbations while on appropriate anti-asthmatic mediations.
• Use of systemic immunosuppressive medications, including, but not limited to, cyclosporine, systemic or intralesional corticosteroids, mycophenolate mofetil, azathioprine, methotrexate, tacrolimus, or ultraviolet (UV) phototherapy with/without Psoralen Ultraviolet A (PUVA) therapy within 4 weeks prior to randomization.
• Use of an oral JAK inhibitor (tofacitinib, ruxolitinib, baricitinib, or investigational oral JAK Inhibitors) within 12 weeks prior to the Baseline visit.
• Subject has been previously treated with dupiliumab.
• Subject has used topical corticosteroids, and/or tacrolimus, and/or pimecrolimus within 1 week before the Baseline visit.
• Subject currently uses or plans to use anti-retroviral therapy at any time during the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Regeneron Pharmaceuticals

INDUSTRY

Sponsor Role: collaborator

Emma Guttman

OTHER

Sponsor Role: lead

Responsible Party

Emma Guttman

Sol and Clara Kest Professor and System Chair

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Emma Guttman-Yassky, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Icahn School of Medicine at Mount Sinai

Locations

University of California, Irvine

Irvine, California, United States

Site Status: RECRUITING

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status: RECRUITING

UR Dermatology at College Town

Rochester, New York, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Giselle Singer

Role: CONTACT

giselle.singer@mssm.edu

212-241-3288

Facility Contacts

Jamy Paniagua

Role: primary

jamyp@hs.uci.edu

(949) 824-7103

Giselle Singer

Role: primary

giselle.singer@mssm.edu

212-241-3288

Alicia Papalia

Role: primary

Alicia_papalia@urmc.rochester.edu

585-273-4195

Other Identifiers

STUDY-22-01021

Identifier Type: -

Identifier Source: org_study_id