Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata

NCT ID: NCT07133308

Last Updated: 2026-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

355 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-05

Study Completion Date

2028-05-31

Brief Summary

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This study evaluates the safety and effectiveness of deuruxolitinib in adolescents aged 12 to less than 18 years who have 50% or greater scalp hair loss.

Detailed Description

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The efficacy and safety of deuruxolitinib in adolescent subjects with severe alopecia areata will be evaluated in this study, beginning with a double-blind, randomized, placebo-controlled Treatment Period of 24 weeks. Subjects 12 to \<18 years of age having at least 50% hair loss as measured by SALT and meeting eligibility criteria will be randomized to deuruxolitinib or placebo treatment. In the Open-label Extension part of the study, participants from the Treatment Period will receive deuruxolitinib for 52 weeks.

Conditions

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Alopecia Areata

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Treatment period:

Model- Parallel Assignment, Number of Arms- 2

The Treatment period will be followed by the Open-Label Extension Period:

Model- Single Group Assignment, Number of Arms- 1
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
All study subjects, Investigators, and site study staff will be blinded to study \[Treatment Period\] followed by None \[Open-Label Extension\]

Study Groups

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Treatment Period: Deuruxolitinib 8 mg

Deuruxolitinib tablets, orally, twice daily (BID) for up to 24 weeks

Group Type EXPERIMENTAL

Deuruxolitinib

Intervention Type DRUG

Deuruxolitinib will be dosed orally as tablets at a dose of 8 mg

Treatment Period: Placebo

Deuruxolitinib-matched placebo tablets, orally, BID for up to 24 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Deuruxolitinib matching placebo will be dosed orally as tablets

Open-Label Extension: Deuruxolitinib 8 mg BID

Deuruxolitinib tablets, orally, BID for up to 52 weeks

Group Type EXPERIMENTAL

Deuruxolitinib

Intervention Type DRUG

Deuruxolitinib will be dosed orally as tablets at a dose of 8 mg

Interventions

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Deuruxolitinib

Deuruxolitinib will be dosed orally as tablets at a dose of 8 mg

Intervention Type DRUG

Placebo

Deuruxolitinib matching placebo will be dosed orally as tablets

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical presentation compatible with alopecia areata with a current episode lasting at least 6 months and not exceeding 10 years.
* Between 12 to \<18 years of age
* At least 50% scalp hair loss, as defined by a Severity of Alopecia Tool (SALT) score ≥50.
* Willing to comply with the study visits and requirements of the study protocol

Exclusion Criteria

* Active scalp inflammation, psoriasis, or seborrheic dermatitis requiring topical treatment to the scalp, significant trauma to the scalp, or other scalp condition that may interfere with the SALT assessment, or untreated actinic keratosis at Screening and/or Baseline
* Treatment with other medications or agents within 28 days of Baseline or during the study that may affect hair regrowth or immune response.
* Females who are nursing, pregnant, or planning to become pregnant while in the study, and for 30 days after last dose of study drug.
* Clinically significant medical condition, psychiatric disease, or social condition, as determined by the Investigator, that may unfavorably alter the risk-benefit of study participation, adversely affect study compliance, or confound interpretation of study results.
Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sun Pharmaceutical Industries, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Total Skin And Beauty Dermatology Center

Birmingham, Alabama, United States

Site Status RECRUITING

Avacare - Cct Research - Center For Dermatology And Plastic Surgery

Scottsdale, Arizona, United States

Site Status RECRUITING

Dermatology Trial Associates

Bryant, Arkansas, United States

Site Status RECRUITING

Kern Research Inc.

Bakersfield, California, United States

Site Status RECRUITING

Center For Dermatology Clinical Research Inc.

Fremont, California, United States

Site Status RECRUITING

Dermatology Research Associates

Los Angeles, California, United States

Site Status RECRUITING

Palmtree Clinical Research

Palm Springs, California, United States

Site Status RECRUITING

Paradigm Clinical Research - San Diego

San Diego, California, United States

Site Status RECRUITING

Colorado Medical Research Center

Denver, Colorado, United States

Site Status RECRUITING

Paradigm Clinical Research - Wheat Ridge

Wheat Ridge, Colorado, United States

Site Status RECRUITING

D&H Doral Research Center

Doral, Florida, United States

Site Status RECRUITING

Skin Care Research, Llc - Hollywood

Hollywood, Florida, United States

Site Status RECRUITING

Ilumina Medical Research Llc

Kissimmee, Florida, United States

Site Status RECRUITING

All X Ray Diagnostic Services Corp

Miami, Florida, United States

Site Status RECRUITING

Millennium Medical Research Llc

Miami, Florida, United States

Site Status RECRUITING

Florida International Medical Research

Miami, Florida, United States

Site Status RECRUITING

Florida Pharmaceutical Research And Associates, Inc.

Miami, Florida, United States

Site Status RECRUITING

L&C Professional Medical Research Institute

Miami, Florida, United States

Site Status RECRUITING

Pediatric Skin Research Llc

Miami, Florida, United States

Site Status RECRUITING

Valencia Medical & Research Center

Miami, Florida, United States

Site Status RECRUITING

Advance Research Center, Llc

Miami, Florida, United States

Site Status RECRUITING

Barroso Medical Services Llc

Miami Lakes, Florida, United States

Site Status RECRUITING

Nexus Research Llc

Pompano Beach, Florida, United States

Site Status RECRUITING

International Clinical Research Us Llc - Sanford

Sanford, Florida, United States

Site Status RECRUITING

Lenus Research & Medical Group Llc.

Sweetwater, Florida, United States

Site Status RECRUITING

Cleaver Medical Group Dermatology

Cumming, Georgia, United States

Site Status RECRUITING

Skin Care Physicians Of Georgia

Macon, Georgia, United States

Site Status RECRUITING

Georgia Skin & Cancer Clinic

Savannah, Georgia, United States

Site Status RECRUITING

Asr, Llc

Boise, Idaho, United States

Site Status RECRUITING

Denova Research

Chicago, Illinois, United States

Site Status RECRUITING

Ds Research - Indiana

Clarksville, Indiana, United States

Site Status RECRUITING

Dawes Fretzin Clinical Research Group Llc.

Indianapolis, Indiana, United States

Site Status RECRUITING

Ds Research - Kentucky

Louisville, Kentucky, United States

Site Status RECRUITING

U.S. Dermatology Partners - Rockville

Rockville, Maryland, United States

Site Status RECRUITING

Oakland Hills Dermatology

Auburn Hills, Michigan, United States

Site Status RECRUITING

Revival Research Institute, Llc - Troy, Mi

Troy, Michigan, United States

Site Status RECRUITING

Medisearch Clinical Trials

Saint Joseph, Missouri, United States

Site Status RECRUITING

Boeson Research Mso

Missoula, Montana, United States

Site Status RECRUITING

Skin Specialists, Pc

Omaha, Nebraska, United States

Site Status RECRUITING

Schweiger Dermatology & Allergy - Verona

Verona, New Jersey, United States

Site Status RECRUITING

Vitality Clinical Trials

Woodbury, New York, United States

Site Status RECRUITING

Revival Research Institute, Llc - Cary, Nc

Cary, North Carolina, United States

Site Status RECRUITING

Darst Dermatology

Charlotte, North Carolina, United States

Site Status RECRUITING

Dermatologists Of Southwest Ohio

Mason, Ohio, United States

Site Status RECRUITING

Dermatology Associates Of Plymouth Meeting

Plymouth Meeting, Pennsylvania, United States

Site Status RECRUITING

Tribe Clinical Research, Llc

Greenville, South Carolina, United States

Site Status RECRUITING

Delricht Research - Smyrna

Smyrna, Tennessee, United States

Site Status RECRUITING

Dermatology Treatment And Research Center - Dallas

Dallas, Texas, United States

Site Status RECRUITING

North Texas Center For Clinical Research

Frisco, Texas, United States

Site Status RECRUITING

Austin Institute For Clinical Research Inc.

Pflugerville, Texas, United States

Site Status RECRUITING

Texas Dermatology And Laser Specialists

San Antonio, Texas, United States

Site Status RECRUITING

Jordan Valley Dermatology

South Jordan, Utah, United States

Site Status RECRUITING

Avacare - Cct Research - Springville Dermatology

Springville, Utah, United States

Site Status RECRUITING

National Eagle Research, Llc

Lynnwood, Washington, United States

Site Status RECRUITING

Kirk Barber Research

Calgary, Alberta, Canada

Site Status RECRUITING

Dermatology Research Institute (Calgary)

Calgary, Alberta, Canada

Site Status RECRUITING

Alberta Dermasurgery Centre

Edmonton, Alberta, Canada

Site Status RECRUITING

Care Clinic Ltd.

Red Deer, Alberta, Canada

Site Status RECRUITING

Medical Arts Health Research Group - Kelowna

Kelowna, British Columbia, Canada

Site Status RECRUITING

Enverus Medical Research

Surrey, British Columbia, Canada

Site Status RECRUITING

Lynderm Research Inc.

Markham, Ontario, Canada

Site Status RECRUITING

Dr. S. K. Siddha Medicine Professional Corporation

Newmarket, Ontario, Canada

Site Status RECRUITING

Research Toronto

Toronto, Ontario, Canada

Site Status RECRUITING

Facet Dermatology

Toronto, , Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Head Regulatory Affairs

Role: CONTACT

9122 66455645

Other Identifiers

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CP543.3101

Identifier Type: -

Identifier Source: org_study_id

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