Effect of Blueberries on Immunity and Response to Flu Vaccination

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-12

Study Completion Date

2025-12-31

Brief Summary

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This research study will test the effects of almonds on immune functions and immune response to influenza vaccine in overweight older men and postmenopausal women

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Detailed Description

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A free-living parallel, single-blind, RCT will be utilized. There will be two phases: Phase 1 - to examine the effects of Blueberries on plasma markers of immune strength, and Phase 2 - to assess the response to influenza vaccine following blueberry intake. Subjects will either consume their usual diet with (Blueberry group) or a placebo(control group) blueberries for 8 weeks, receive the influenza vaccination, and continue the intervention for another 4 weeks. The test food will be freeze-dried powder (FDP) (\~ to 1 cup fresh blueberries) per day with the usual diet. The control will be the placebo powder with some guidelines to restrict all berries and other polyphenol-rich foods. The entire study will last 12 weeks. Participants will attend a baseline clinic at which time they will be randomized to one of the two groups. Clinic visits will occur at baseline, weeks 4 and 8 before, and week 4 after vaccination.

Conditions

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Immune Response Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

his will be a parallel, free-living, randomized controlled trial, where 52 overweight men and postmenopausal women will be randomized to receive either the freeze dried blueberries or a placebo powder

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

The investigator, participant, care provider, outcomes assessor will not be aware of which participant is in which arm

Study Groups

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Blueberry powder group

Participants in the blueberry powder group will receive freeze dried blueberries in form of a powder

Group Type EXPERIMENTAL