HLH Patients - a Retrospective Study

NCT ID: NCT05531721

Last Updated: 2023-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-10

Study Completion Date

2023-04-30

Brief Summary

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Monocentric, observational, retrospective, no profit study aimed to analyze factors that are significantly impacting the outcome of patients diagnosed with HLH.

Detailed Description

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retrospective data collection to study: type of HLH familial vs secondary, sex, age, presence of infectious cause, involvement central nervous system ( SNC), hepatic involvement, presence of hemophagocytosis, presence of splenomegaly, presence of involvement of other organs, the value of neutrophils (PMN), the value of hemoglobin, platelets, albumin, triglycerides, ferritin, LDH, type of therapy and the response to therapy after 2 months

Conditions

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Hemophagocytic Lymphohistiocytoses

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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pediatric patients affected by hemophagocytic lymphohistiocytoses

pediatric patients with HLH

Observation

Intervention Type OTHER

Observation and retrospective data collection

Interventions

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Observation

Observation and retrospective data collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Have received HLH diagnosis according to HLH 2004 criteria
* age ⥶18 years.
* followed at our facility between January 2004 and December 2021
* Whose parents have consented to participation and data processing
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

OTHER

Sponsor Role lead

Responsible Party

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Prof. Franca Fagioli

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Franca Fagioli, MD

Role: PRINCIPAL_INVESTIGATOR

AOU Città della Salute e della Scienza di Torino - OIRM

Locations

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AOU Città della Salute e della Scienza di Torino - Presidio Infantile Regina Margherita

Turin, , Italy

Site Status

Countries

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Italy

Other Identifiers

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HLH-OIRM

Identifier Type: -

Identifier Source: org_study_id

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