Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease
NCT ID: NCT05511402
Last Updated: 2022-08-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
28 participants
INTERVENTIONAL
2022-08-25
2022-12-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Aerobic exercise
This group will participate in an aerobic training program (8-week, 3 times weekly, and 30-min each time) and conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).
Exercise training
People with Parkinson's Disease will be received a supervised physiotherapy and rehabilitation program.
Conventional physiotherapy
This group will participate in a conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).
Exercise training
People with Parkinson's Disease will be received a supervised physiotherapy and rehabilitation program.
Interventions
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Exercise training
People with Parkinson's Disease will be received a supervised physiotherapy and rehabilitation program.
Eligibility Criteria
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Inclusion Criteria
* diagnosed with Parkinson's Disease
* Hoehn and Yahr stage of 1 and 3
Exclusion Criteria
* any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training
* visual, auditory, and perception problems.
40 Years
ALL
No
Sponsors
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Gazi University
OTHER
Saglik Bilimleri Universitesi
OTHER
Responsible Party
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Fatih Söke
Assistant Professor
Principal Investigators
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Ayse Bora Tokcaer, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
Gazi University
Locations
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Saglik Bilimleri Universitesi
Ankara, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8. doi: 10.1002/ana.10483.
Elokda A, DiFrancisco-Donoghue J, Lamberg EM, Werner WG. Effects of exercise induced oxidative stress on glutathione levels in Parkinson's disease on and off medication. J Neurol. 2010 Oct;257(10):1648-53. doi: 10.1007/s00415-010-5584-6. Epub 2010 May 12.
Dani C, Proenca IT, Marinho J, Peccin P, da Silva IRV, Nique S, Striebel V, Pochmann D, Elsner VR. Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease. Neural Regen Res. 2020 Nov;15(11):2067-2072. doi: 10.4103/1673-5374.276337.
Xu X, Fu Z, Le W. Exercise and Parkinson's disease. Int Rev Neurobiol. 2019;147:45-74. doi: 10.1016/bs.irn.2019.06.003. Epub 2019 Jun 20.
Khan Z, Ali SA. Oxidative stress-related biomarkers in Parkinson's disease: A systematic review and meta-analysis. Iran J Neurol. 2018 Jul 6;17(3):137-144.
Yuan Y, Tong Q, Zhang L, Jiang S, Zhou H, Zhang R, Zhang S, Xu Q, Li D, Zhou X, Ding J, Zhang K. Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients. Int J Neurosci. 2016;126(7):641-6. doi: 10.3109/00207454.2015.1054031. Epub 2015 Jul 14.
Dumitrescu L, Marta D, Danau A, Lefter A, Tulba D, Cozma L, Manole E, Gherghiceanu M, Ceafalan LC, Popescu BO. Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson's Disease. Front Neurosci. 2021 Jun 18;15:689723. doi: 10.3389/fnins.2021.689723. eCollection 2021.
Smeyne M, Smeyne RJ. Glutathione metabolism and Parkinson's disease. Free Radic Biol Med. 2013 Sep;62:13-25. doi: 10.1016/j.freeradbiomed.2013.05.001. Epub 2013 May 8.
Martin HL, Teismann P. Glutathione--a review on its role and significance in Parkinson's disease. FASEB J. 2009 Oct;23(10):3263-72. doi: 10.1096/fj.08-125443. Epub 2009 Jun 19.
Other Identifiers
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630
Identifier Type: -
Identifier Source: org_study_id
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