Study of PBK_L1704 for the Treatment of Moderate to Severe Acute Pain After Bunionectomy in South Korea

NCT ID: NCT05509868

Last Updated: 2022-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

225 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-20

Study Completion Date

2022-12-30

Brief Summary

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The primary objective is to evaluate the analgesic efficacy of PBK\_L1704 compared with placebo in patients with moderate to severe acute pain after bunionectomy.

Detailed Description

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Conditions

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Acute Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel Assignment
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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PBK_L1704 0.35mg

Group Type EXPERIMENTAL

PBK_L1704 0.35mg

Intervention Type DRUG

The subject will receive PBK\_L1704 0.35mg/ml by PCA

PBK_L1704 0.5mg

Group Type EXPERIMENTAL

PBK_L1704 0.5mg

Intervention Type DRUG

The subject will receive PBK\_L1704 0.5mg/ml by PCA

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

The subject will receive placebo by PCA

Interventions

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PBK_L1704 0.35mg

The subject will receive PBK\_L1704 0.35mg/ml by PCA

Intervention Type DRUG

PBK_L1704 0.5mg

The subject will receive PBK\_L1704 0.5mg/ml by PCA

Intervention Type DRUG

Placebo

The subject will receive placebo by PCA

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Scheduled to undergo primary, unilateral, first metatarsal bunionectomy with osteotomy and internal fixation
* Able to understand and comply with the study procedures and requirements, and able to provide written informed consent before any study procedure.

Exclusion Criteria

* Participated in another oliceridine clinical study.
* Received any investigational drug, device or therapy within 35 days before surgery.
* Clinically significant medical, surgical, postsurgical, psychiatric or substance abuse condition or history of such condition that could confound the interpretation of efficacy, safety or tolerability data in the study.
* American Society of Anesthesiologists (ASA) Physical Status Classification System classification III or worse.
Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pharmbio Korea Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lee

Role: PRINCIPAL_INVESTIGATOR

Seoul Asan Medical Center

Locations

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Seoul Asan medical Center

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Manager Clinical Trial team, Pharmbio Korea

Role: CONTACT

+82-2-587-2551

Other Identifiers

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PBK_L1704_301

Identifier Type: -

Identifier Source: org_study_id

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