Impact of Preoperative Oral Branched-chain Amino Acids on Reducing Postoperative Insulin Resistance.
NCT ID: NCT05494658
Last Updated: 2024-03-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
224 participants
INTERVENTIONAL
2022-08-26
2024-12-31
Brief Summary
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There is a clear link between postoperative insulin resistance and poor perioperative prognosis. Therefore, exploring interventions to reduce postoperative stress insulin resistance, stabilize postoperative blood glucose, and reduce postoperative complications are clinical problems that need to be solved urgently. In recent years, research on branched-chain amino acids and metabolic diseases has become a hot spot. Studies have found that in the rat model, preoperatively given a high branched-chain amino acid diet can inhibit postoperative insulin resistance and stabilize blood glucose levels. This research plan is to try to add branched-chain amino acids before surgery to observe the occurrence of postoperative insulin resistance in patients.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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research group
600ml drink which contains 18g BCAA was consumed by patients 2-4h before surgery.
BCAA
600ml drink which contains 18g BCAA was consumed by patients 2-4h before surgery.
control group
600ml water was consumed by patients 2-4h before suegery.
water
600ml water was consumed by patients 2-4h before suegery.
Interventions
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BCAA
600ml drink which contains 18g BCAA was consumed by patients 2-4h before surgery.
water
600ml water was consumed by patients 2-4h before suegery.
Eligibility Criteria
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Inclusion Criteria
2. Clinical diagnosis of colorectal cancer;
3. Planned elective laparoscopic radical resection of colorectal cancer;
4. Preoperative American Society of Anesthesiologists（ASA）score grade I-III ;
5. Informed consent was obtained from patients.
Exclusion Criteria
2. Preoperative insulin resistance ;
3. Renal insufficiency requires dialysis, hepatic insufficiency (Child - Pugh grade B and above);
4. Eating disorders caused by gastrointestinal obstruction;
5. Pregnant or lactating women;
6. Patients with severe mental illness.
50 Years
80 Years
ALL
No
Sponsors
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Huashan Hospital
OTHER
Yangpu District Central Hospital Affiliated to Tongji University
OTHER
Sun Peng
OTHER
Responsible Party
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Sun Peng
Executive Director of General Surgery
Locations
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Shanghai Tongren Hospital
Shanghai, , China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022-050-01
Identifier Type: -
Identifier Source: org_study_id
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