Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
13 participants
INTERVENTIONAL
2023-09-01
2024-05-01
Brief Summary
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Detailed Description
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Participants will be undertaking a 12-week home-based high-intensity interval training intervention. The programme is a feasibility study, previously co-created by people with Parkinson's and clinicians within an iterative planning process of focus groups and exercise testing.
Following recruitment, participants will undertake initial baseline assessments. These will involve collection of anthropometric measurements and general lifestyle and Parkinson's related information, followed by pre-intervention mechanistic, physiological and clinical outcome measures. Participants will then be randomised to the HIIT intervention, or usual care control group.
Both groups will then undertake 7 days pre-intervention physical activity monitoring following accelerometer instruction, as a baseline measure of habitual physical activity (an important confounding variable).
Following an initial home visit, participants will then undertake a 12-week high-intensity interval training programme in the home setting, with supplied exercise equipment including music and exercise prompts, and remote support and online resources. Participants will complete a 32 minute training session 3 times per week, with at least one day of rest between sessions. Participants will be loaned heart rate monitoring devices, which will remotely record heart rate per exercise session. During week 7 of the intervention, participants will be asked to repeat 7 days of accelerometer wearing to compare habitual physical activity. Participants will record feasibility and safety aspects such as HIIT participation / adverse effects and events / exercise adaptations in diaries during the course of the intervention.
Participants will then undergo post-intervention outcome measures. Participants will also be asked to be involved in a 45-minute post intervention focus group as part of a process evaluation. Depending on numbers, it is likely that there will be 2 of these parallel groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Exercise
High-intensity interval training plus usual care
High-intensity interval training
12-weeks of high intensity interval exercise, 30 minutes thrice weekly
Usual care
Usual care / treatment. Usual physical activity.
No interventions assigned to this group
Interventions
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High-intensity interval training
12-weeks of high intensity interval exercise, 30 minutes thrice weekly
Eligibility Criteria
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Inclusion Criteria
* Aged 18 years or older (No upper limit)
* Hoehn and Yahr stages 1-3 (Mild to moderate disease severity)
* Capacity to consent under the Mental Capacity Act 2005, and able to follow an exercise programme
* Based at home with enough space to perform an exercise programme
* Willing and able to travel to intervention assessments
* Access to a computer, Smart Phone, or tablet and to the internet.
Exclusion Criteria
* Co-morbidities that would prevent / be exacerbated by high-intensity exercise such as forms of cardiovascular disease
* Advised to not participate following medical consultation
* Participation in a contemporaneous interventional study
18 Years
ALL
No
Sponsors
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University of Plymouth
OTHER
Responsible Party
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(Ivan) Conrad Harpham
PhD student, Principal Investigator
Locations
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University Hospitals Plymouth NHS Trust
Plymouth, Devon, United Kingdom
Countries
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References
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Harpham C, Gunn H, Marsden J, Bescos-Garcia R, Murgatroyd C, Connolly L. Home-Based High-Intensity Interval Training for People With Parkinson's: A Randomized, Controlled, Feasibility Trial. Health Sci Rep. 2025 Jul 14;8(7):e71024. doi: 10.1002/hsr2.71024. eCollection 2025 Jul.
Other Identifiers
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UPlymouthCH
Identifier Type: -
Identifier Source: org_study_id
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