BIPAP in the Management of Acute Respiratory Distress Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-20

Study Completion Date

2022-07-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Evaluation of biphasic positive airway pressure as a new mode of ventilation in management of acute respiratory failure constituted in ARDS as a category of hypoxaemic respiratory failure in comparison to conventional ventilation.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Compare Between APRV and Bipap Ventilation in ARDS Patients

NCT06755320

ARDS: Acute Respiratory Distress Syndrome ARDS

NOT_YET_RECRUITING NA

n-CPAP Versus n-BiPAP and NIPPV for Postextubation in RDS in Preterms

NCT01770925

Respiratory Distress Syndrome

COMPLETED NA

HFNO VERSUS BIPAP IN PREECLAMPTIC PATIENTS WITH ACUTE HYPOXAEMIC RESPIRATORY FAILURE

NCT07084870

HFNO vs BIPAP Preeclamptic Acute Hypoxaemic Respiratory Failure

COMPLETED NA

Effect of Selected Evidence-based Practices and Related Nurses' Education on the Incidence and Severity of Ventilator-associated Pneumonia

NCT05877105

Evidence-based Practices Nursing Education Incidence +1 more

COMPLETED NA

Feasibility Study to Compare Two Ventilatory Modes for Mechanical Ventilation Weaning

NCT06912906

Mechanical Ventilation Weaning

NOT_YET_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Biphasic positive airway pressure (BIPAP) is a mode of mechanical ventilation that allow unrestricted spontaneous breathing independent of ventilator cycling, using an active expiratory valve. BIPAP mode is pressure-limited and time-cycled, Ventilation occurs via the time-cycled switching between two set pressure levels. In the absence of spontaneous breathing, this mode resemble conventional pressure controlled ventilation.

A proposed advantage of BIPAP compared to conventional pressure-controlled ventilation is the improved distribution of gas to dependent lung regions as the result of spontaneous breathing enabled during the inspiratory and expiratory time cycles, so prevents atelectasis and promotes alveolar recruitment resulting in an improved ventilation-perfusion matching.

ARDS is an acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung tissue with hypoxemia and bilateral radiographic opacities, associated with increased venous admixture, increased physiological dead space and decreased lung compliance.

In patients with ARDS, BIPAP with spontaneous breathing contributes to improved pulmonary gas exchange, systemic blood flow and oxygen supply to the tissue. This is reflected by clinical improvement in the patient's condition, which is associated with significantly fewer days on ventilatory support, earlier extubation and a shorter stay in the intensive care unit.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Mechanical Ventilation Complication

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

BIPAP mode of ventilation applied to 20patients , SIMV PC mode applied to the other group

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Mechanically ventilated ARDS patients

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

BIPAP group

Mechanically ventilated ARDS patients on BIPAP mode of ventilation

Group Type EXPERIMENTAL

BIPAP mode/SIMV PC mode

Intervention Type OTHER

BIPAP is a mode of ventilation recently used in ARDS

SIMV PC group

Mechanically ventilated ARDS patients on SIMV PC mode of ventilation

Group Type EXPERIMENTAL

BIPAP mode/SIMV PC mode

Intervention Type OTHER

BIPAP is a mode of ventilation recently used in ARDS

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

BIPAP mode/SIMV PC mode

BIPAP is a mode of ventilation recently used in ARDS

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All intubated Adult ARDS patients
* ARDS is diagnosed according to berlin criteria.

Exclusion Criteria

* Age \< 18 years.
* Cardiac or respiratory arrest on admission.
* Morbid obesity with BMI \> 40.
* Acute exacerbation of IPF.
* Cerebrovascular or neuro muscular disorder. 6. Diabetic ketoacidosis. 7. Hepatic or renal disease. 8.Cardiac disease.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No