A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis
NCT ID: NCT05482256
Last Updated: 2025-10-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2022-09-12
2023-02-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Toothpaste detergents with Eosinophilic Esophagitis Testing
Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste.
Esophageal String Test (EST)
Non-invasive, FDA-registered sampling method to evaluate eosinophilic inflammation in the esophagus. The EST is performed by having an individual swallow a capsule attached to a string which captures secretions from the esophagus. The end of the string is taped to the cheek and the capsule is swallowed with water. After 1 hour, the EST will be removed, and the string will be processed for laboratory analysis.
Colgate
2 grams of toothpaste (pea sized amount) for 2 minutes
High Resolution Esophageal Manometry (HREM)
Thin flexible tube with sensors placed in the nose and swallowed for esophagus placement to conduct reading regarding the lining of the esophagus taken for approximately 10 minutes
Interventions
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Esophageal String Test (EST)
Non-invasive, FDA-registered sampling method to evaluate eosinophilic inflammation in the esophagus. The EST is performed by having an individual swallow a capsule attached to a string which captures secretions from the esophagus. The end of the string is taped to the cheek and the capsule is swallowed with water. After 1 hour, the EST will be removed, and the string will be processed for laboratory analysis.
Colgate
2 grams of toothpaste (pea sized amount) for 2 minutes
High Resolution Esophageal Manometry (HREM)
Thin flexible tube with sensors placed in the nose and swallowed for esophagus placement to conduct reading regarding the lining of the esophagus taken for approximately 10 minutes
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Able to swallow pills.
Exclusion Criteria
* History of dysphagia (i.e., difficulty swallowing), chronic vomiting, chronic abdominal pain, unintentional weight loss.
* Celiac disease, inflammatory bowel disease, irritable bowel syndrome, esophageal varices, chronic aspiration, connective tissue disorder, or known parasitic infection.
* Gelatin allergy.
* Use of a toothpaste containing SLS within 2 weeks of the study.
* Pregnancy.
18 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Benjamin L. Wright
Principal Investigator
Principal Investigators
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Benjamin Wright, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic Arizona
Scottsdale, Arizona, United States
Countries
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Related Links
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Mayo Clinic - Clinical Trials
Other Identifiers
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22-003963
Identifier Type: -
Identifier Source: org_study_id
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