Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
120 participants
INTERVENTIONAL
2023-06-18
2023-10-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Control group
A bolus of normal saline (2 ml) by IV was given 5 min before spinal anesthesia.
normal saline
A bolus of normal saline (2 ml) by IV was given 5 min before spinal anesthesia.
Ondansetron 4 mg
A bolus of ondansetron (2 ml; 4mg) by IV was given 5 min before spinal anesthesia.
Ondansetron 4 mg
A bolus of ondansetron (2 ml; 4mg) by IV was given 5 min before spinal anesthesia.
Ondansetron 8 mg
A bolus of ondansetron (2 ml; 8mg) by IV was given 5 min before spinal anesthesia.
Ondansetron 8 mg
A bolus of ondansetron (2 ml; 8mg) by IV was given 5 min before spinal anesthesia.
Interventions
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normal saline
A bolus of normal saline (2 ml) by IV was given 5 min before spinal anesthesia.
Ondansetron 4 mg
A bolus of ondansetron (2 ml; 4mg) by IV was given 5 min before spinal anesthesia.
Ondansetron 8 mg
A bolus of ondansetron (2 ml; 8mg) by IV was given 5 min before spinal anesthesia.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Primipara or multipara
* Singleton pregnancy ≥ 37 weeks
* American Society of Anesthesiologists physical status classification I to II
* Scheduled for elective cesarean section under spinal anesthesia
Exclusion Criteria
* Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
* Eclampsia or chronic hypertension or baseline blood pressure ≥ 160mmHg
* Hemoglobin \< 7g/dl
* Fetal distress, or known fetal developmental anomaly
18 Years
45 Years
FEMALE
No
Sponsors
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General Hospital of Ningxia Medical University
OTHER
Responsible Party
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Principal Investigators
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Yi Chen, M.D.
Role: STUDY_CHAIR
General Hospital of Ningxia Medical University
Locations
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General Hospital of Ningxia Medical University
Yinchuan, , China
Countries
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References
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Qin R, Xu X, Zhao N, Shi Y, Chen Y, Chen J, Ni X. Effect of different prophylactical doses of ondansetron for the hemodynamic stability in patients undergoing cesarean section: a randomized controlled study. Front Med (Lausanne). 2025 Apr 3;12:1495721. doi: 10.3389/fmed.2025.1495721. eCollection 2025.
Other Identifiers
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Yi Chen-2022-1
Identifier Type: -
Identifier Source: org_study_id
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