Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
400 participants
OBSERVATIONAL
2023-10-01
2024-05-01
Brief Summary
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Detailed Description
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Administration of ondansetron prior to spinal anesthesia can attenuate hypotension and bradycardia.
Aim:
Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of Ondansetron can reduce incidence of hypotension and bradycardia associated with spinal in cesarean section, and to identify the optimal timing and dose for administration.
Objectives:
* Primary outcome: incidence of hypotension after spinal anaesthesia in the patients who received Ondansetron and those who did not
* Secondary outcome : use of vasopressors , bradycardia , timing of administration of Ondansetron wether it is more or less than five minutes prior to the administration of anesthesia.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Intravenous Ondansetron for patients undergoing Cesarean section under spinal Anesthesia
Pregnant patients undergoing elective caesarean section with no co-morbidities will receive intravenous ondansetron
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Eclampsia
* Hypertension
* Diabetes
FEMALE
Yes
Sponsors
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Kuwait Institute for Medical Specialization
OTHER_GOV
Assiut University
OTHER
Responsible Party
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Abdelrady S Ibrahim, MD
Professor of Anesthesia and ICU
Principal Investigators
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Abdelrady S Ibrahim, .M.D.
Role: PRINCIPAL_INVESTIGATOR
Assiut University Faculty Of Medicine
Locations
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Assiut university faculty of medicine
Asyut, , Egypt
Countries
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References
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Hofhuizen C, Lemson J, Snoeck M, Scheffer GJ. Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients. Local Reg Anesth. 2019 Mar 4;12:19-26. doi: 10.2147/LRA.S193925. eCollection 2019.
Other Identifiers
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Kuwait MOH
Identifier Type: OTHER
Identifier Source: secondary_id
IRB0000871252
Identifier Type: -
Identifier Source: org_study_id
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