Integral Physiological Adaptations to Carbohydrate Periodization

NCT ID: NCT05464342

Last Updated: 2023-06-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 45 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-07-05
• Study Completion Date: 2023-05-31

Brief Summary

The purpose of this study is to examine the effect of long-term carbohydrate periodization protocols on sleep architecture, sleep quality, daytime sleepiness, physical performance, body composition, gut microbiome, and miRNA in healthy trained individuals.

Detailed Description

Athletic populations have been particularly susceptible to sleep inadequacies, experience several sleep issues, and fall below the age-specific sleep recommendations. However, it is well demonstrated that exercise does not impair sleep by itself, and furthermore, acute post-exercise nutrition could elevate the exercise-induced sleep-optimizing effect, with further benefits for the next physical performance. In line with these findings, in a metanalysis of clinical trials, it was shown that pre-bed carbohydrate availability resulted in significant alterations in sleep architecture. It is of utmost importance to highlight that throughout this metanalysis, it was revealed that no long-term nutrition intervention for sleep optimization has been studied yet. These data raise the question of whether a long-term carbohydrate periodization protocol could optimize sleep and alter gut function in a way that athletic performance will be also enhanced. This would allow elucidating further potential interrelations and biological pathways underlying these adaptations.

Conditions

Sleepiness; Fatigue; Feeding Patterns; Daytime Sleepiness, Excessive

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Evening LGI Carbohydrate Consumption

Dietary Intervention: Consumption of Low Glyceamic Index (LGI) carbohydrates intake post-workout/evening.

Group Type: EXPERIMENTAL

Evening LGI Carbohydrate Consumption Group

Intervention Type: BEHAVIORAL

Participants will receive in the evening food with low glycemic index

Evening HGI Carbohydrate Consumption

Dietary Intervention: Consumption of High Glyceamic Index (HGI) carbohydrates intake post-workout/evening.

Group Type: EXPERIMENTAL

Evening HGI Carbohydrate Consumption

Intervention Type: BEHAVIORAL

Participants will receive in the evening food with high glycemic index

Evening NO-CHO Carbohydrate Consumption

Dietary Intervention: No consumption of carbohydrates intake post-workout/evening.

Group Type: EXPERIMENTAL

Evening NO-CHO Carbohydrate Consumption

Intervention Type: BEHAVIORAL

Participants will receive in the evening a meal with no carbohydrates at all.

Interventions

Evening LGI Carbohydrate Consumption Group

Participants will receive in the evening food with low glycemic index

Intervention Type: BEHAVIORAL

Evening HGI Carbohydrate Consumption

Participants will receive in the evening food with high glycemic index

Intervention Type: BEHAVIORAL

Evening NO-CHO Carbohydrate Consumption

Participants will receive in the evening a meal with no carbohydrates at all.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Both sexes, Age between 18 and 50 yrs old, Regularly participating in sports activities.

Exclusion Criteria

• Any kind of history of major diseases or medication, Excessive amounts of alcohol and caffeine consumption

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Nicosia

OTHER

Sponsor Role: collaborator

University of Cyprus

OTHER

Sponsor Role: collaborator

University of Thessaly

OTHER

Sponsor Role: lead

Responsible Party

Giorgos K. Sakkas

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Georgios Sakkas, PhD

Role: STUDY_CHAIR

University of Thessaly

Locations

Department of Life and Health Sciences

Nicosia, , Cyprus

Lifestlye Medicine Laboratory, TEFAA, University of Thessaly

Trikala, Thessaly, Greece

Countries

Cyprus; Greece

References

Vlahoyiannis A, Andreou E, Aphamis G, Felekkis K, Pieri M, Sakkas GK, Giannaki CD. Evaluating the evening carbohydrate dilemma: the effect of within-the-day carbohydrate periodization on body composition and physical fitness. Eur J Nutr. 2024 Nov 25;64(1):23. doi: 10.1007/s00394-024-03540-6.

Reference Type: DERIVED

PMID: 39585451 (View on PubMed)

Vlahoyiannis A, Andreou E, Bargiotas P, Aphamis G, Sakkas GK, Giannaki CD. The effect of chrono-nutritional manipulation of carbohydrate intake on sleep macrostructure: A randomized controlled trial. Clin Nutr. 2024 Mar;43(3):858-868. doi: 10.1016/j.clnu.2024.02.016. Epub 2024 Feb 15.

Reference Type: DERIVED

PMID: 38367595 (View on PubMed)

Other Identifiers

EEBK/EΠ/2018/10

Identifier Type: -

Identifier Source: org_study_id