Preoperative Renal Insufficiency Predicts Postoperative Adverse Outcomes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2421286 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-07-01

Brief Summary

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The main purpose of this study is to evaluate the risk of postoperative mortality and complications in surgical populations with preoperative renal insufficiency.

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Detailed Description

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This retrospective cohort study use the National Surgical Quality Improvement Program (NSQIP) database to evaluate the risk of postoperative morbidity and mortality in the surgical population. Patients with estimated. glomerular filtration rate(GFR) \< 60 ml/min per 1.73 square meter are defined as the renal insufficiency group. Patients with estimated GFR \> 90 ml/min per 1.73 square meter are defined as patients without renal insufficiency. Propensity score-matching methods and multivariate logistic regression are used to calculate the risk of postoperative morbidity and mortality.

Conditions

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Renal Insufficiency Morality

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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renal insufficiency group

1. Surgical population currently on dialysis
2. Surgical population with estimated GFR \< 60 ml/min per 1.73 square meter within 90days before the index surgery. The estimated GFR

estimated GFR calculation

Intervention Type DIAGNOSTIC_TEST

The estimated GFR is computed with Modification of Diet in Renal Disease (MDRD) formula

Non-renal insufficiency group

Defined as the study subjects with eGFR \> 90 60 ml/min per 1.73 square meter within 90 days before the index surgery

estimated GFR calculation

Intervention Type DIAGNOSTIC_TEST

The estimated GFR is computed with Modification of Diet in Renal Disease (MDRD) formula

Interventions

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estimated GFR calculation

The estimated GFR is computed with Modification of Diet in Renal Disease (MDRD) formula

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients with estimated GFR \< 60 ml/min per 1.73 square meter or currently on dialysis are included in renal insufficiency group.
* Patients with estimated GFR \> 90 ml/min per 1.73 square meter are included in non-renal insufficiency group