Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

NCT ID: NCT05452382

Last Updated: 2022-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2607 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-01

Study Completion Date

2022-07-06

Brief Summary

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A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Detailed Description

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Conditions

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Appendiceal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Partial colectomy

Patients with appendiceal cancer who underwent segmental resection of appendiceal adenocarcinoma

Partial colecctomy

Intervention Type PROCEDURE

Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum

Hemicolectomy

Patients with appendiceal cancer who underwent formal right hemicolectomy of appendiceal adenocarcinoma

Hemicolectomy

Intervention Type PROCEDURE

Formal right hemicolectomy including terminal ileum, cecum, and ascending colon

Interventions

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Partial colecctomy

Segmental resection of appendiceal adenocarcinoma including terminal ileum and cecum

Intervention Type PROCEDURE

Hemicolectomy

Formal right hemicolectomy including terminal ileum, cecum, and ascending colon

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection

Exclusion Criteria

* Patients with other pathologic types of appendiceal cancer
* Patients with clinical stage IV or unknown stage
* Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cleveland Clinic Florida

OTHER

Sponsor Role collaborator

Mansoura University

OTHER

Sponsor Role lead

Responsible Party

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Sameh Emile

Research associate

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cleveland Clinic Flroida

Weston, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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NCDBAppendix

Identifier Type: -

Identifier Source: org_study_id

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