Loss of Autonomy in the Elderly: Relationships Between Gut Microbiota Diversity, Nutrition and Cognitive and Sensory-motor Disturbances in "Small Eaters" and "Non Small Eaters"
NCT ID: NCT05449119
Last Updated: 2024-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
140 participants
OBSERVATIONAL
2023-06-13
2028-06-30
Brief Summary
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We will study the relationship between the deterioration of cognitive and sensorimotor function, diet and intestinal well-being (i.e. microbiota) of a cohort of older adults (\>75 years) defined as "small eaters" from their admission in EHPAD at the University Hospital of Dijon. This study will be carried out by a unique French multidisciplinary consortium that includes academics and health professionals, who will be able to specify the criteria defining the "small eaters" and to envisage suitable dietary strategies aiming to preserve their nutritional status and intestinal well-being. The final goal is to improve quality of life at home by prolonging autonomy and independence, and thus to deferring admission to an EHPAD for as long as possible.
The objective of this study is to build a cohort of elderly "small eaters" and a cohort of elderly "non small eaters". These patients will be followed over a period of one year. The evolution of the composition of the intestinal microbiota will be determined in order to establish the existing relations between the composition of digestive microbiota, the nutritional state, and cognitive and sensorimotor function.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Non small eaters
Elderly subjects who are not malnourished
Fecal and blood sampling and collection of nutritional, cognitive and sensorimotor data
at T0, T3 months, T6 months, T9 months and T12 months
Body Mass Index (BMI)
Calculation of BMI with height measurement by heel-knee distance measurement at T0, T3 months, T6 months, T9 months and T12 months
24-hour food and beverage record
at T0, T3 months, T6 months, T9 months and T12 months
Mini Nutritional assessment (MNA)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of muscle mass by bioelectrical impedance analysis (except for participants with a pacemaker)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of sensorimotor functions
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of cognitive functions
at T0, T3 months, T6 months, T9 months and T12 months
Small eaters
Elderly subjects with loss of appetite
Fecal and blood sampling and collection of nutritional, cognitive and sensorimotor data
at T0, T3 months, T6 months, T9 months and T12 months
Body Mass Index (BMI)
Calculation of BMI with height measurement by heel-knee distance measurement at T0, T3 months, T6 months, T9 months and T12 months
24-hour food and beverage record
at T0, T3 months, T6 months, T9 months and T12 months
Mini Nutritional assessment (MNA)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of muscle mass by bioelectrical impedance analysis (except for participants with a pacemaker)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of sensorimotor functions
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of cognitive functions
at T0, T3 months, T6 months, T9 months and T12 months
Interventions
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Fecal and blood sampling and collection of nutritional, cognitive and sensorimotor data
at T0, T3 months, T6 months, T9 months and T12 months
Body Mass Index (BMI)
Calculation of BMI with height measurement by heel-knee distance measurement at T0, T3 months, T6 months, T9 months and T12 months
24-hour food and beverage record
at T0, T3 months, T6 months, T9 months and T12 months
Mini Nutritional assessment (MNA)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of muscle mass by bioelectrical impedance analysis (except for participants with a pacemaker)
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of sensorimotor functions
at T0, T3 months, T6 months, T9 months and T12 months
Measurement of cognitive functions
at T0, T3 months, T6 months, T9 months and T12 months
Eligibility Criteria
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Inclusion Criteria
* A person over 75 years of age residing in an EHPAD who may be under guardianship or curatorship.
* A person over 75 years of age with a loss of appetite (i.e. a small eater) residing in an EHPAD, who may be under guardianship or curatorship.
Exclusion Criteria
* Elderly person with an infectious syndrome at the time of admission;
* Elderly person with diarrhoea (infectious or not) at the time of admission;
* Elderly person receiving recently prescribed antimicrobials at the time of admission (antibiotics or antifungals)
* Elderly person with celiac disease and/or Crohn's disease.
* Person under a measure of limited judicial protection
75 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Dijon
OTHER
Responsible Party
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Locations
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Chu Dijon Bourgogne
Dijon, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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DALLE CHU 2020
Identifier Type: -
Identifier Source: org_study_id
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