Genoss DES in Patients With a High Risk of Ischemic Events (GENTLE Registry)

NCT ID: NCT05448625

Last Updated: 2025-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-05-26

Study Completion Date

2025-09-23

Brief Summary

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This is a prospective cohort study to evaluate the long-term effect and safety of Genoss drug-eluting stents (DES) in patients with coronary artery disease with high ischemic features.

Detailed Description

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It is known that ischemic events after percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) increase as the anatomical, physiological, or functional complexity of coronary artery disease increases. Recently, the concept of complex higher-risk and clinically indented procedure (CHIP) has been proposed, which includes patients with various medical conditions, patients with various heart conditions, and patients with technically complex PCI. Until now, Genoss stents have no data on the evaluation of stents in patients with coronary artery disease and high ischemic features.

Conditions

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Drug-eluting Stent Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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High Ischemic Group

1. Acute myocardial infarction (AMI)
2. ≥ 2 stents implanted
3. bifurcation lesion
4. Left main lesion
5. Lesion treated with rotational atherectomy
6. Chronic total occlusion (CTO) lesion

Genoss DES

Intervention Type DEVICE

The Genoss DES (Genoss, Korea) L-605 cobalt chromium (CoCr) platform with a strut thickness of 70 µm Sirolimus drug with concentration of 1.15µg/mm2 Abluminal biodegradable PLA and PLGA polymers.

Interventions

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Genoss DES

The Genoss DES (Genoss, Korea) L-605 cobalt chromium (CoCr) platform with a strut thickness of 70 µm Sirolimus drug with concentration of 1.15µg/mm2 Abluminal biodegradable PLA and PLGA polymers.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is ≥ 19 years
* Subject has signed informed consent for data release

Exclusion Criteria

* Subject did not sign informed consent for data release
* Known intolerance to aspirin, clopidogrel, ticlopidine, heparin or any other anticoagulation / antiplatelet therapy required for PCI, cobalt chromium, Sirolimus or contrast media
* Pregnancy
* Subject with life expectancy less than 12 months
* Subject with cardiogenic shock
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Severance Hospital

OTHER

Sponsor Role collaborator

Genoss Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Yongcheol Kim

Clinical Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Deok-Kyu Cho, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Yongin Severance Hopistal

Locations

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Yongin Severance Hospital

Yongin, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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9-2022-0014

Identifier Type: -

Identifier Source: org_study_id

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