Evaluation of the First, Second, and New Drug-Eluting Stents in Routine Clinical Practice

NCT ID: NCT01186133

Last Updated: 2025-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2030-12-31

Brief Summary

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The objective of this study is to evaluate effectiveness and safety of the new drug-eluting stent (DES), as compared with the first-,second-,third-, and fourth-generation DES, in the "real world" daily practice.

Detailed Description

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Consecutive patients receiving New DES without a mixture of other DES

Conditions

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Coronary Artery Disease Percutaneous Transluminal Coronary Angioplasty

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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DESSIAN

consecutive patients receiving CYPHER stent

No interventions assigned to this group

K-XIENCE

consecutive patients receiving Xience stent

No interventions assigned to this group

GENOUS

consecutive patients receiving GENOUS stent

No interventions assigned to this group

ELEMENT

consecutive patients receiving PROMUS-ELEMENT stent

No interventions assigned to this group

PRIME

consecutive patients receiving XIENCE-PRIME stent

No interventions assigned to this group

NOBORI

consecutive patients receiving NOBORI stent

No interventions assigned to this group

INTEGRITY

consecutive patients receiving RESOLUTE-INTEGRITY stent

No interventions assigned to this group

XPEDITION

consecutive patients receiving XIENCE-XPEDITION stent

No interventions assigned to this group

BIOMATRIX

consecutive patients receiving BIOMATRIX stent

No interventions assigned to this group

CILOTAX

consecutive patients receiving CILOTAX stent

No interventions assigned to this group

DEB

consecutive patients receiving Drug eluting balloon

No interventions assigned to this group

DESYNE

consecutive patients receiving DESYNE stent

No interventions assigned to this group

PREMIER

consecutive patients receiving PROMUS-PREMIER stent

No interventions assigned to this group

ORSIRO

consecutive patients receiving ORSIRO stent

No interventions assigned to this group

ONYX

consecutive patients receiving ONYX stent

No interventions assigned to this group

BVS

consecutive patients receiving Bioresorbable Vascular Scaffold

No interventions assigned to this group

BVS AMI

consecutive acute myocardial infarction patients receiving Bioresorbable Vascular Scaffold

No interventions assigned to this group

Ultimaster

consecutive patients receiving Ultimaster stent

No interventions assigned to this group

Synergy

consecutive patients receiving Synergy stent

No interventions assigned to this group

Biofreedom

consecutive patients receiving Biofreedom stent

No interventions assigned to this group

Firehawk

consecutive patients receiving Firehawk stent

No interventions assigned to this group

DESyne X2

consecutive patients receiving DESyne X2 stent

No interventions assigned to this group

Sierra

consecutive patients receiving Sierra stent

No interventions assigned to this group

Tansei

consecutive patients receiving Tansei stent

No interventions assigned to this group

Synergy XD and Synergy Megatron™

consecutive patients receiving Synergy XD or Synergy Megatron™ stent

No interventions assigned to this group

Xience-Skypoint

consecutive patients receiving Xience-Skypoint stent

No interventions assigned to this group

Coroflex ISAR NEO

consecutive patients receiving Coroflex ISAR NEO stent

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* coronary disease amenable to percutaneous coronary intervention (PCI)
* no clinical and lesion limitations

Exclusion Criteria

* patients with a mixture of several DES
* terminal illness with life expectancy less than 1 year
* patients with cardiogenic shock
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CardioVascular Research Foundation, Korea

OTHER

Sponsor Role collaborator

Seung-Jung Park

OTHER

Sponsor Role lead

Responsible Party

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Seung-Jung Park

MD,PhD, Chairman,Heart Institute, Asan Medical Center,University of Ulsan,College of Medicine

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Seung-Jung Park, MD

Role: STUDY_CHAIR

Asan Medical Center

Locations

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Korean centres

Multiple Locations, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Seung-Jung Park, MD

Role: CONTACT

Duk-Woo Park, MD

Role: CONTACT

References

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Kim TO, Kang DY, Ahn JM, Kim MJ, Lee PH, Kim H, Choi Y, Lee J, Lee JM, Jo HH, Park YS, Lim SM, Park SJ, Park DW. Impact of Target Lesion Revascularization on Long-Term Mortality After Percutaneous Coronary Intervention for Left Main Disease. JACC Cardiovasc Interv. 2024 Jan 8;17(1):32-42. doi: 10.1016/j.jcin.2023.10.068.

Reference Type DERIVED
PMID: 38199751 (View on PubMed)

Jeong YJ, Hyun J, Lee J, Kim JH, Yang Y, Choe K, Lee JS, Park H, Cho SC, Kang DY, Lee PH, Ahn JM, Park DW, Park SJ; IRIS-DES Registry Investigators. Comparison of Contemporary Drug-Eluting Stents in Patients Undergoing Complex High-Risk Indicated Procedures. JACC Asia. 2022 Mar 1;2(2):182-193. doi: 10.1016/j.jacasi.2021.10.008. eCollection 2022 Apr.

Reference Type DERIVED
PMID: 36339122 (View on PubMed)

Yang Y, Hyun J, Lee J, Kim JH, Lee JB, Kang DY, Lee PH, Ahn JM, Park DW, Park SJ; IRIS-DES Registry Investigators. Effectiveness and Safety of Contemporary Drug-Eluting Stents in Patients With Diabetes Mellitus. JACC Asia. 2021 Sep 21;1(2):173-184. doi: 10.1016/j.jacasi.2021.07.009. eCollection 2021 Sep.

Reference Type DERIVED
PMID: 36338165 (View on PubMed)

Park S, Ahn JM, Kim TO, Park H, Cho SC, Kang DY, Lee PH, Park DW, Park SJ; IRIS-DES Registry Investigators. Incidence and Impact of Thrombocytopenia in Patients Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents. Am J Cardiol. 2020 Nov 1;134:55-61. doi: 10.1016/j.amjcard.2020.07.059. Epub 2020 Aug 16.

Reference Type DERIVED
PMID: 32891400 (View on PubMed)

Park H, Ahn JM, Kang DY, Lee JB, Park S, Ko E, Cho SC, Lee PH, Park DW, Kang SJ, Lee SW, Kim YH, Lee CW, Park SW, Park SJ. Optimal Stenting Technique for Complex Coronary Lesions: Intracoronary Imaging-Guided Pre-Dilation, Stent Sizing, and Post-Dilation. JACC Cardiovasc Interv. 2020 Jun 22;13(12):1403-1413. doi: 10.1016/j.jcin.2020.03.023. Epub 2020 May 27.

Reference Type DERIVED
PMID: 32473888 (View on PubMed)

Lee CH, Ahn JM, Lee KS, Kang DY, Lee PH, Lee SW, Lee CW, Park SW, Park DW, Park SJ; IRIS-DES Registry Investigators. Prevalence, predictors, prognostic significance, and effect of techniques on outcomes of coronary lesion calcification following implantation of drug-eluting stents: a patient-level pooled analysis of stent-specific, multicenter, prospective IRIS-DES registries. Coron Artery Dis. 2021 Jan;32(1):42-50. doi: 10.1097/MCA.0000000000000896.

Reference Type DERIVED
PMID: 32310851 (View on PubMed)

Lee CH, Kang DY, Han M, Hur SH, Rha SW, Her SH, Seung KB, Kim KS, Lee PH, Ahn JM, Lee SW, Park SW, Park DW, Park SJ; IRIS-DES Registry Investigators. Differential cutoff points and clinical impact of stent parameters of various drug-eluting stents for predicting major adverse clinical events: An individual patient data pooled analysis of seven stent-specific registries and 17,068 patients. Int J Cardiol. 2019 May 1;282:17-23. doi: 10.1016/j.ijcard.2019.01.108. Epub 2019 Feb 2.

Reference Type DERIVED
PMID: 30745256 (View on PubMed)

Lee PH, Kwon O, Ahn JM, Lee CH, Kang DY, Lee JB, Kang SJ, Lee SW, Kim YH, Lee CW, Park SW, Park DW, Park SJ. Safety and Effectiveness of Second-Generation Drug-Eluting Stents in Patients With Left Main Coronary Artery Disease. J Am Coll Cardiol. 2018 Feb 27;71(8):832-841. doi: 10.1016/j.jacc.2017.12.032.

Reference Type DERIVED
PMID: 29471933 (View on PubMed)

Other Identifiers

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2010-035

Identifier Type: -

Identifier Source: org_study_id

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