iTBS Can Increase Frontal Dopamine Release in PET Dopamine Imaging.
NCT ID: NCT05448430
Last Updated: 2022-07-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2022-07-15
2024-07-01
Brief Summary
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2\. Our previous study found patients with negative symptoms have more possibilities to have disorders in glucose metabolism, we wonder whether dopamine release, negative symptoms or glucose metabolism can be improved by iTBS.
Study design: Case control study.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
SCREENING
DOUBLE
Study Groups
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predominant negative symptoms
iTBS for predominant negative symptoms
Theta burst stimulation
a new paradigm of high frequency repetitive transcranial magnetic stimulation
positive symptoms
No interventions assigned to this group
healthy control
No interventions assigned to this group
Interventions
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Theta burst stimulation
a new paradigm of high frequency repetitive transcranial magnetic stimulation
Eligibility Criteria
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Inclusion Criteria
* Positive and Negative Syndrome Scale factor score for negative symptoms of 24 or moreand score of 4 or more on at least two of three core negative PANSS items
* PANSS for positive symptoms of 19 or less, and HAMD depression scale of 16 or less.
* PANSS for positive symptoms of 20 or more
* drug-naive
Exclusion Criteria
* diagnosed with other major mental disorders according to ICD-10 or DSM-V
18 Years
65 Years
ALL
Yes
Sponsors
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Central South University
OTHER
Responsible Party
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Renrong Wu
Professor
Locations
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Central South University
Changsha, Hunan, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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WU2022PETTMS
Identifier Type: -
Identifier Source: org_study_id
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