Surgiphor vs Saline Joints

NCT ID: NCT05434260

Last Updated: 2023-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

868 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-19

Study Completion Date

2025-01-31

Brief Summary

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This study will be an open-label superiority, multicenter, single-blind, controlled randomized clinical trial investing the role of a PVP-I irrigation solution (Surgiphor) in reducing the risk of acute PJI in the 90 days following total hip and knee revision arthroplasty.

Detailed Description

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Conditions

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Prosthetic-joint Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Surgiphor: sterile povidone iodine irrigation solution

Surgiphor Wound Irrigation Solution, bottle consisting of sterile 0.5% PVP-I formulation with 0.9% saline, Potassium Iodide, Phosphate Buffer, Vitamin E TPGS

Group Type ACTIVE_COMPARATOR

Surgiphor Irrigation Solution

Intervention Type DEVICE

use of Surgiphor wound irrigation solution during surgery

Sterile saline

Group Type PLACEBO_COMPARATOR

Sterile saline

Intervention Type DEVICE

Use of sterile saline as a irrigation solution during surgery

Interventions

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Surgiphor Irrigation Solution

use of Surgiphor wound irrigation solution during surgery

Intervention Type DEVICE

Sterile saline

Use of sterile saline as a irrigation solution during surgery

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient ≥18 years old
2. Male or non-pregnant, non-lactating, postmenopausal or surgically sterilized females
3. Subjects scheduled to undergo total knee or total hip revision for aseptic reasons (per 2018 ICM criteria 5)
4. Subjects provide informed consent, which will consist of reading, signing, and dating the informed consent document after the Investigator, sub-Investigator or other designated study staff member has explained the study procedures, risks, and contact information. Subjects not willing to sign consent form to be randomized must be willing to sign alternate consent form to allow prospective data collection in the non-randomized arm of the study

Exclusion Criteria

1. Subjects with known allergies to iodine or any other ingredients in Surgiphor
2. Subjects unwilling to sign informed consent
3. Subjects, for health reasons or other, in the opinion of the Investigator, with a life expectancy less than one year, which is the follow-up period of the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Center for Innovation and Research Organization

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Arizona

Phoenix, Arizona, United States

Site Status

Lifebridge Health

Baltimore, Maryland, United States

Site Status

University of Missouri

Columbia, Missouri, United States

Site Status

Rothman Institute Orthopaedics

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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Surgiphor01

Identifier Type: -

Identifier Source: org_study_id

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