Cologne Placenta Cohort (CPC)

NCT ID: NCT05424965

Last Updated: 2022-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

247 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-23

Study Completion Date

2022-12-31

Brief Summary

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Aim of the study was to determine if signaling pathways in placentas of mothers affected by overweight/obesity or by gestational diabetes are altered compared to placentas of a control group (normal weight, no gestational diabetes). Moreover, maternal blood and umbilical cord blood were analysed.

Detailed Description

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Conditions

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Obesity, Maternal Gestational Diabetes Mellitus in Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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normal weight without gestational diabetes

BMI \< 25; normal glucose tolerance

no intervention

Intervention Type OTHER

no intervention

normal weight with gestational diabetes

BMI \< 25; impaired oral glucose tolerance

no intervention

Intervention Type OTHER

no intervention

overweight without gestational diabetes

BMI 25 - 29.9; normal glucose tolerance

no intervention

Intervention Type OTHER

no intervention

overweight with gestational diabetes

BMI 25 - 29.9; impaired glucose tolerance

no intervention

Intervention Type OTHER

no intervention

obese without gestational diabetes

BMI \>= 30; normal glucose tolerance

no intervention

Intervention Type OTHER

no intervention

obese with gestational diabetes

BMI \>= 30; impaired glucose tolerance

no intervention

Intervention Type OTHER

no intervention

Interventions

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no intervention

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* singleton pregnancy
* BMI before pregnancy \>= 18
* with \& without gestational diabetes
* c-section at gestational week 35+0 until 41+6

Exclusion Criteria

* multiple pregnancy
* maternal serious internal disease
* infections before pregnancy (e.g. HIV, hepatitis B)
* pregnancy-associates diseases (e.g. gestoses, androgen insensitivity syndrome)
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Sarah Appel

OTHER

Sponsor Role lead

Responsible Party

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Sarah Appel

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Sarah Appel, Dr.

Role: PRINCIPAL_INVESTIGATOR

Universitätsklinikum Köln

Locations

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University Hospital of Cologne

Cologne, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

Other Identifiers

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14-244

Identifier Type: -

Identifier Source: org_study_id

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