Subclinical Hypothyrodism and Ovarian Reserve

NCT ID: NCT05409729

Last Updated: 2022-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2023-08-01

Brief Summary

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This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve

Primary outcome:

Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

Detailed Description

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Thyroid dysfunction is one of the commonest disorders in women of reproductive age .there is association between subclinical hypothyrodism and infertility and ovarian reserve .It's known that subclinical hypothyrodism can be associated with reduced ovarian reserve in women more than 35 years old .Aclear association between subclinical hypothyrodism and ovarian reserve not established in reproductive age in women less than 35 .This retrospective study investigate serum thyroid hormone /Antithyroid hormone ,ovarian reserve markers (basal FSH,AMH,Antral follicle count on day 2-4/prolactin level .

Conditions

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Fertility Disorders

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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retrospective charts reviewing

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* All reproductive age groups included women less than 35 and women more than 35

Exclusion Criteria

* Previous ovarian surgery Women with long term thyroid hormone replacement Endometriosis History of radiotheraby
Minimum Eligible Age

13 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Eman Ahmed Abed Eltawaab Abdo

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Assiut Medical School

Asyut, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Eman Ahmed Abed Eltawaab, MBBCH

Role: CONTACT

01065933793

Facility Contacts

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Eman Ahmed Abed Eltawaab, MBBCH

Role: primary

01065933793

References

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Rao M, Wang H, Zhao S, Liu J, Wen Y, Wu Z, Yang Z, Su C, Su Z, Wang K, Tang L. Subclinical Hypothyroidism Is Associated with Lower Ovarian Reserve in Women Aged 35 Years or Older. Thyroid. 2020 Jan;30(1):95-105. doi: 10.1089/thy.2019.0031. Epub 2019 Dec 20.

Reference Type RESULT
PMID: 31650898 (View on PubMed)

Korevaar TIM, Minguez-Alarcon L, Messerlian C, de Poortere RA, Williams PL, Broeren MA, Hauser R, Souter IC. Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care. Thyroid. 2018 Oct;28(10):1349-1358. doi: 10.1089/thy.2017.0582. Epub 2018 Aug 14.

Reference Type RESULT
PMID: 29943679 (View on PubMed)

Other Identifiers

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AMH

Identifier Type: -

Identifier Source: org_study_id

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