Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

NCT ID: NCT05390281

Last Updated: 2025-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-01

Study Completion Date

2020-10-01

Brief Summary

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Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Detailed Description

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Conditions

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Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pre-diabetic group

Patients with preoperative HbA1c 5.7-6.4% (group A) (prediabetics)

increase in serum creatinine

Intervention Type DIAGNOSTIC_TEST

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Diabetic group

Patients with preoperative HbA1c \> or = 6.5% till 7% or \> 7% in case of emergency surgery or rapidly progressive cases with no time for long-term glycemic control (group B) (diabetics)

increase in serum creatinine

Intervention Type DIAGNOSTIC_TEST

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Interventions

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increase in serum creatinine

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* ASA physical status II-III
* scheduled to undergo isolated coronary artery bypass grafting

Exclusion Criteria

* Patients with history of renal failure
* Patients with history of hepatic failure
* Patients with history of heart failure
* previous cardiac surgery
* cerebrovascular event in the last 30 days
* percutaneous coronary intervention in the last 30 days prior to operation
* peripheral arterial disease
* malignancy
* infectious diseases
* patients who required surgical revision
* patients who required postoperative intra-aortic balloon pump
* patients with CBP time \> 120 min or aortic cross clamp time \> 90 min
Minimum Eligible Age

45 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Ghada M.Samir

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ain-Shams University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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FMASU MD 368/2018

Identifier Type: -

Identifier Source: org_study_id

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