Nafamostat Mesilate for Anticoagulation During CRRT in Critically Ill Patients

NCT ID: NCT05382078

Last Updated: 2022-05-19

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 188 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-05-31
• Study Completion Date: 2024-05-03

Brief Summary

Continuous renal replacement therapy is widely used in intensive care medicine, which is known as an alternative therapy to save injured kidney . Anticoagulation is an important part of this therapy. An insufficient anticoagulation would cause a poor curative effect of CRRT. Hemorrhage，heparin-induced thrombocytopenia (HIT), citrate accumulation, acidosis ad filter extra-cost usually happened on anticoagulation during CRRT. Therefore a new effective anticoagulation of CRRT needs to be carried out. Nafamostat Mesylate (NM) is a new anticoagulant. This serine protease inhibitor with broad spectrum can inhibit kinds of enzymes on the process of coagulation. NM is mainly rapidly decomposed in the liver and also removed by dialysis or filtration. The elimination half life of is only 8 minutes. If NM is applied as a regional anticoagulant, approximate 40% NM is removed by dialysis and / or convection in cardiopulmonary bypass circuit, and then rapidly degraded by esterase in liver and blood, which ensures security in patients with bleeding tendency.

Based on the information above, the investigators designed an observational clinical study aimed to testify that NM would have equivalent anticoagulant results compared with those traditional ways and might even have a better effect than traditional anticoagulant therapy.The study team has investigated the current situation of CRRT in Shaanxi province in China through a cross-sectional survey last year. The survey involved 74 hospitals in Shaanxi province and the results basically illustrated a real status of CRRT. These scientific results helped investigators to design this multi-center, parallel, controlled, non intervention study and real world study.

Detailed Description

CRRT, the continuous renal replacement therapy, is widely applied in the field of intensive care medicine. This technology is known as an alternative therapy to save injured kidney with advantages of the accurate volume control, stable acid-alkali electrolyte equilibrium maintenance and hemodynamic stability.

Anticoagulation is an important part of this therapy. An ideal anticoagulant and a reasonable anticoagulation process would help CRRT function well. Therefor an insufficient anticoagulation would cause a poor curative effect of CRRT.

Heparins, reginal citrate anticoagulant (RCA) and anticoagulant-free are the most common methods applied in CRRT. However, heparins would lead to hemorrhage and heparin-induced thrombocytopenia (HIT). And RCA is the absolute contraindication of liver failure and shock status, which would easily cause citrate accumulation and acidosis. While anticoagulant-free method is often suitable for patients with acute hepatic failure, citrate metabolic disorder, sever acidosis and coagulation dysfunction. According to aforementioned reasons, a new effective anticoagulation of CRRT needs to be carried out.

Nafamostat Mesylate (NM) is a late-model anticoagulant. This serine protease inhibitor with broad spectrum can inhibit kinds of enzymes on the process of coagulation. It has strong inhibitory effects on thrombin, coagulation factors Ⅻ a, Xa, VIIa, kallikrein, fibrinolytic enzyme, complement system C1r, C1s and trypsin. NM is mainly rapidly decomposed by carboxylesterase in the liver and also removed by dialysis or filtration. The elimination half life of is only 8 minutes. If NM is applied as a reginal anticoagulant, approximate 40% NM is removed by dialysis and / or convection in cardiopulmonary bypass circuit, and then rapidly degraded by esterase in liver and blood, which ensures security in patients with bleeding tendency.

Based on the information above, the investigators designed an observational clinical study aimed to testify that NM would have equivalent anticoagulant results compared with those traditional ways and might even have a better effect than traditional anticoagulant therapy.

In this study, the average filter life-span will be calculated and compared in groups to assess effectiveness of NM. And the safety of NM will be assessed by comparing the incidence rate of the bleeding and/or massive hemorrhage between groups. Besides, the best dose of NM will be titrated during the trial along with targeting a best monitoring value of NM.

Either in the observational or in the control group, the continuous renal replacement therapy should be implemented as indications. The investigators need to record trial details into an eCRF as protocol required. The details include main diagnosis, clinical status before first CRRT, the primary indications for first CRRT, the coagulation function, laboratory indexes, the frequency and site of hemorrhage, the incidence of hyper-coagulable state, the average life-span of filters during first CRRT, the number of filters caused by clotting, and times of transfusion.

The anticoagulation in observational arm will be implemented as follows.

1. Admixture: to fully dissolve 50mg NM into 5% glucose solution.

2. Pipeline pre-flushing: to dissolve 50mg NM into 1000ml 5% glucose solution. to prime the filters and extracorporeal circuits with the mixtures above. Then to use 5% glucose solution and 0.9% saline solution sequentially flushing the pipe-line and filters for a complete elution and to ensure the drug residue would be as less as possible.

3. Drug infusion: The maintaining dose of NM is 10-20mg/hr.

4. Monitoring: APTT will be tested every 30min to 2h initially. The goal of APTT is settled as 80s-100s in circuits and as 40s-50s in body. Once the steady state is reached, the monitoring interval will be adjusted to 12~24h. To reach the target monitoring goal, the NM will be added or reduced by 2~4mg each time.

While in control group, the CRRT steps will be implemented by Standard operating procedures for blood purification(version2021, China).

Data collection and safety: in this study, an independent offline eCRF will be applied in collecting data. Specific staff will be trained to use eCRF correctly and collect data regularly. The details are displayed in CRF.

Conditions

Sepsis Syndrome; MODS; AKI; Hemorrhage; Trauma; Thrombus

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Critically ill patients admitted to ICU
• ICU patients requiring further CRRT due to renal or non-renal indications
• signed informed consent

Exclusion Criteria

• The hospitalization stay of ICU is less than 24 hours.
• The case data are incomplete.
• age<18 and ≥85
• patients suffering from metal illness or unable to cooperate for some certain reasons
• allergic to NM or Pharmaceutical excipient or extracorporeal circuit consumables
• preparing for pregnancy/pregnant/ during lactation period
• patients or their agents refuse to sign the informed consent form or participate in another clinical trial
• non-compliant, lost visit or other situations that patients are unsuitable for selection determined by researchers

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 84 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Second Affiliated Hospital of Xi'an Jiaotong University

OTHER

Sponsor Role: collaborator

Tang-Du Hospital

OTHER

Sponsor Role: collaborator

Xi'an Gaoxin Hospital

OTHER

Sponsor Role: collaborator

Affiliated Chest Hospital Xi'an Jiaotong University

UNKNOWN

Sponsor Role: collaborator

Xi'an Honghui Hospital

OTHER

Sponsor Role: collaborator

Shangluo Central Hospital

OTHER

Sponsor Role: collaborator

Yulin first Hospital

UNKNOWN

Sponsor Role: collaborator

Yan'an University Affiliated Hospital

OTHER

Sponsor Role: collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Qindong Shi, Chief

Role: STUDY_CHAIR

First Affiliated Hospital Xi'an Jiaotong University

Locations

First Affiliated Hospital of Xian JiaotongUniversity

Xi'an, Shaanxi, China

Countries

China

Central Contacts

Qindong Shi, Senior

Role: CONTACT

shiqindong@163.com

0086-18991232391

Sha Sha, Junior

Role: CONTACT

arztinss@163.com

0086-18629560399

Other Identifiers

XJTU1AF2022LSK-202

Identifier Type: -

Identifier Source: org_study_id