Citrate Anticoagulation for Postdilution Hemofiltration

NCT ID: NCT03969966

Last Updated: 2020-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-14

Study Completion Date

2021-07-31

Brief Summary

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This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.

Detailed Description

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Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects.

We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol.

We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.

Conditions

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Acute Kidney Injury Critical Illness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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renal replacement therapy as clinically indicated

Continuous renal replacement therapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* acute kidney injury
* critical illness and treatment at ICU

Exclusion Criteria

* age \< 18 years
* pregnancy or breast feeding
* severe lactate acidosis ( \> 10 mmol/l) for longer than 6 hours and pH \< 7.2
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Diamed GmbH, Cologne, Germany

UNKNOWN

Sponsor Role collaborator

Heinrich-Heine University, Duesseldorf

OTHER

Sponsor Role lead

Responsible Party

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Klinik für Anästhesiologie

Prof. Dr. D. Kindgen-Milles

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Intensivstation ZOM1 Klinik für Anästhesiologie Universitätsklinikum Düsseldorf

Düsseldorf, , Germany

Site Status RECRUITING

Countries

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Germany

Facility Contacts

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Kindgen-Milles, MD

Role: primary

+49 211 81 ext. 07049

References

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Dimski T, Brandenburger T, Vollmer C, Kindgen-Milles D. A safe and effective protocol for postdilution hemofiltration with regional citrate anticoagulation. BMC Nephrol. 2024 Jul 9;25(1):218. doi: 10.1186/s12882-024-03659-y.

Reference Type DERIVED
PMID: 38982339 (View on PubMed)

Other Identifiers

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2018-82

Identifier Type: -

Identifier Source: org_study_id

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