Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury
NCT ID: NCT03236441
Last Updated: 2025-01-09
Study Results
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View full resultsBasic Information
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COMPLETED
NA
110 participants
INTERVENTIONAL
2018-03-06
2024-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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RIPC Group
3 cycles of blood pressure cuff inflations to occlusive pressure of 200 mmHg for 5 minutes and deflation for 5 minutes
RIPC
Remote ischemic preconditioning
Sham-RIPC Group
3 cycles of blood pressure cuff inflations to non-occlusive pressure of 10 mmHg for 5 minutes and deflation for 5 minutes (Control)
Sham-RIPC
Control
Interventions
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RIPC
Remote ischemic preconditioning
Sham-RIPC
Control
Eligibility Criteria
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Inclusion Criteria
* Referral for cardiac catheterization and percutaneous coronary intervention
* Contrast-induced acute kidney injury risk score of ≥11
Exclusion Criteria
* unstable blood pressure (systolic blood pressure \> 200 or \<90 mmHg)
* History of allergy to contrast media
* Peripheral vascular disease of upper limb
* Renal disease requiring dialysis
* Placement of arteriovenous fistula and arteriovenous graft
18 Years
ALL
No
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Oladipupo Olafiranye, MD, MS
OTHER
Responsible Party
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Oladipupo Olafiranye, MD, MS
Associate Professor of Medicine
Principal Investigators
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Oladipupo Olafiranye, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
VA Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, United States
Countries
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References
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Olafiranye O, Straub AC, Zhang Y, Chaudhary R, Miller MP, Trivedi K, Hoang L, Khalifa O, Ladejobi A, Thoma FW, Feng N, Rahman A, Kellum JA; BRICK Trial Investigators. Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography: The BRICK Randomized Clinical Trial. JACC Adv. 2025 Sep;4(9):102092. doi: 10.1016/j.jacadv.2025.102092. Epub 2025 Aug 23.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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STUDY19090247
Identifier Type: -
Identifier Source: org_study_id
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