Thyroid Nodule Gene Sequencing in a Danish Population

NCT ID: NCT05377736

Last Updated: 2025-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-01

Study Completion Date

2027-01-18

Brief Summary

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This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.

Patients with thyroid nodules suspected of malignancy is included prospectively.

Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.

Detailed Description

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Conditions

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Thyroid Nodule (Diagnosis) Thyroid Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Molecular testing

Descriptive and explorative study including identical molecular analyses applied to all included patients

Group Type EXPERIMENTAL

Molecular analyses

Intervention Type GENETIC

Collect thyroid tissue for molecular analysis from the histological specimen collected by routine surgery

Interventions

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Molecular analyses

Collect thyroid tissue for molecular analysis from the histological specimen collected by routine surgery

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Thyroid nodule \>1.5 cm
* BSRTC: IV, V, og VI

Exclusion Criteria

* No surgical specimen available
* Purely cystic nodules
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Kristine Zøylner Rubeck

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kristine Z Swan

Role: PRINCIPAL_INVESTIGATOR

Aarhus University Hospital

Locations

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Aarhus Universityhospital

Aarhus N, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Thy-sec-da 032022

Identifier Type: -

Identifier Source: org_study_id

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