Mobility and Voiding Exercises in Older Women With Urinary Incontinence (MoVEonUp)

NCT ID: NCT05375344

Last Updated: 2025-07-11

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 375 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-06-09
• Study Completion Date: 2026-08-31

Brief Summary

A prospective, two-arm randomized clinical trial utilizing a multidimensional intervention to reduce falls in older women with Urinary Urge Incontinence. The intervention consist of general balance and strength training, bladder training and urge suppression, and home hazard assessments. The control group will receive informational booklets on fall prevention and behavioral treatment for urinary urge incontinence.

Conditions

Urinary Incontinence, Urge

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Exercise Group

Participants in this group will participate in the home-based exercise group intervention that consists of general balance and strength training, bladder training and urge suppression, and home hazard assessments.

Group Type: ACTIVE_COMPARATOR

Exercise Group

Intervention Type: BEHAVIORAL

Home-based exercise group intervention

Control Group

Participants in this group will receive informational booklets on fall prevention and behavioral treatment for Urgency Incontinence.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Exercise Group

Home-based exercise group intervention

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Female
• 70 or older
• Living independently in the community
• Willingness to be randomized.
• Ability to read and understand English
• Be able to provide informed consent
• Low physical activity (physically active for 30 minutes or more less than or equal to 2 days per week on average over the past 6 months) per PAS
• Ambulatory (defined as patient not confined to bed or wheelchair OR ability to walk with or without an assistive device)
• Self-reported moderate to severe urge-predominant UI based on the ICIQ-SF > 6 (Q 1+2+3)
• Not planning to initiate new UI or overactive bladder (OAB) treatment during the study duration
• Capable of participation in an exercise program without exacerbating any pre-existing condition(s), as determined by the study PI or designee

Exclusion Criteria

• Pelvic organ prolapse passed the hymen (per patient report)
• Undergoing active treatment for cancer (other than non-melanoma skin cancer)
• Uncorrected visual or hearing loss.
• Other urinary conditions or procedures that may affect continence status for example: urethral diverticulum, previous augmentation cystoplasty
• Progressive neurodegenerative disease e.g. Parkinson's disease, multiple sclerosis per patient report
• History of stroke or carotid sensitivity (i.e. syncopal falls) per patient report
• Unstable cardiac disease per patient report
• Fracture or joint replacement within the last six months per patient report
• Significant cognitive impairment (defined as a modified TICs score of < 27)
• Per PI discretion, participant cannot enroll in study

• Minimum Eligible Age: 70 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

University of Pennsylvania

OTHER

Sponsor Role: lead

Responsible Party

Uduak Andy

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Uduak U Andy, MD

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Uduak U Andy, MD

Role: CONTACT

uduakumoh.andy@pennmedicine.upenn.edu

(215) 662-7709

Julia Vresilovic

Role: CONTACT

julia.vresilovic@pennmedicine.upenn.edu

Facility Contacts

Uduak Andy, MD

Role: primary

UduakUmoh.Andy@pennmedicine.upenn.edu

Lisa Borodyanskaya

Role: backup

Yelizaveta.Borodyanskaya@pennmedicine.upenn.edu

References

Andy UU, Newman DK, Wyman JF, Klusaritz H, Walsh W, Shou H, Koepler N, Schmitz KH, Reaves S, Arya L, Brown RT. The Mobility and Voiding Exercises in Older Women with Urinary Incontinence (MoVEonUp) randomized controlled trial: study protocol and rationale. BMC Geriatr. 2024 Dec 4;24(1):994. doi: 10.1186/s12877-024-05552-7.

Reference Type: DERIVED

PMID: 39633261 (View on PubMed)

Other Identifiers

849788

Identifier Type: -

Identifier Source: org_study_id