Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2020-03-31
2021-09-15
Brief Summary
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Detailed Description
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We will analyse serially collected serum from 10 dialysis patients, after ingestion of a single vitamin K supplement, compared to healthy controls. Lipoprotein fractions will be isolated and the corresponding vitamin K contents will be measured by chromatography.
The vitamin K supplement contains 3 subforms of vitamin K: vitamin K1 (1000µg), menaquinone-4 (1000µg) and menaquinone-7 (200µg).
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Vitamin K supplement
Administration of a single dose vitamin K
Vitamin K supplement
Single dose of vitamin K supplement
Interventions
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Vitamin K supplement
Single dose of vitamin K supplement
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Controls: adequate kidney function (GFR \> 60 ml/min/1,73m2)
* Patients: chronic haemodialysis
* Written consent to take part in the study
Exclusion Criteria
* gastro-intestinal diseases interfering with vitamin K intake
* profound anemia with an Hb \< 10 g/dl
* judicial or official commitment to an institution
* pregnancy and lactation
18 Years
ALL
Yes
Sponsors
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RWTH Aachen University
OTHER
Responsible Party
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Jürgen Floege
Univ.-Prof. Dr. med.
Principal Investigators
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Jürgen Floege, MD
Role: PRINCIPAL_INVESTIGATOR
RWTH Aachen University
Locations
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RWTH Aachen University
Aachen, , Germany
Countries
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Other Identifiers
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RWTH Aachen University
Identifier Type: -
Identifier Source: org_study_id
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