Impact of Vitamin D on Endothelial Function and Blood Biomarkers Including CD28 Null Cells in CKD

NCT ID: NCT02005718

Last Updated: 2013-12-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-06-30
• Study Completion Date: 2013-06-30

Brief Summary

Vitamin D deficiency is common in CKD and assciated with CV complications. Endothelial dysfucntion is common in CKD and is a harbinger of atherosclerosis. The study investigated the impact of Vitamin D on endothelial fucntion and blood biomarkers in CKD.

Conditions

CKd Patients With Stage 3 and 4

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Vitamin D

Cholecalciferol 300,000 twice

Group Type: EXPERIMENTAL

Cholecalciferol

Intervention Type: DRUG

Interventions

Cholecalciferol

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• CKD 3-4 Age 18-80

Exclusion Criteria

• Recent MI, CVA, malignancy active infection active inflammation High calcium already on Viatmin D therapy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

St George's, University of London

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Debasish Banerjee

Role: PRINCIPAL_INVESTIGATOR

St Georges

References

Chitalia N, Ismail T, Tooth L, Boa F, Hampson G, Goldsmith D, Kaski JC, Banerjee D. Impact of vitamin D supplementation on arterial vasomotion, stiffness and endothelial biomarkers in chronic kidney disease patients. PLoS One. 2014 Mar 19;9(3):e91363. doi: 10.1371/journal.pone.0091363. eCollection 2014.

Reference Type: DERIVED

PMID: 24646518 (View on PubMed)

Other Identifiers

090129

Identifier Type: -

Identifier Source: org_study_id