Changes in Patients' Quality of Life With Differences in Seton Application

NCT ID: NCT05348473

Last Updated: 2022-05-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-12

Study Completion Date

2023-03-12

Brief Summary

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Investigators aim to investigate the changes in patients' quality of life with different type of seton application.

Detailed Description

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Perianal fistula is a very common disease. Perianal fistula develops in the 50% of the anorectal abscess. Perianal fistulas are usually complications of recurrent anorectal abscesses. The management of the fistula is sometimes challenging and requires a long period of time. One of the treatment methods in perianal fistula is seton application. Seton is a rubber band made of various materials such as silicone, silk, latex, etc. It is passed through the fistula tract, and then the tips are tied to each other. Seton is usually kept there for 3 - 6 months depending on the condition of the fistula. Seton causes a foreign body reaction. After this process, there are various fistula management methods. Seton application is again one of the choices besides fistulotomy, fistulectomy, ablation methods, etc.

As seton is a frequently preferred method, patients should get used to living with seton. Severe irritation and a decrease in quality of life are observed in patients depending potentially on the seton binding methods.

Investigators aim to evaluate the seton application methods that will minimize the decrease in the quality of life in this difficult process for patients by comparing 3 different seton application methods that investigators apply in daily practice.

Conditions

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Quality of Life Anal Fistula

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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alpha group

In this group, tips of the seton will be tied as alpha-shaped

Group Type ACTIVE_COMPARATOR

Alpha type

Intervention Type DEVICE

Tips of the seton will be tied as alpha-shaped.

Beta group

The tips of the seton in this group will be overlapped and tied. There is no palpable free ends.

Group Type SHAM_COMPARATOR

Beta type

Intervention Type DEVICE

Tips of the seton in this group will be overlapped and tied

Comfort group

Knotless seton will be applied

Group Type EXPERIMENTAL

Comfort type

Intervention Type DEVICE

Knotless seton will be applied

Interventions

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Alpha type

Tips of the seton will be tied as alpha-shaped.

Intervention Type DEVICE

Beta type

Tips of the seton in this group will be overlapped and tied

Intervention Type DEVICE

Comfort type

Knotless seton will be applied

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* -Primary perianal fistula

Exclusion Criteria

* Suprasphincteric fistula
* Patient who had previous perianal fistula surgery
* Crohn
* Radiotherapy
* Patient with pre-existing anal incontinence
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ankara University

OTHER

Sponsor Role lead

Responsible Party

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Cihangir Akyol

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mehmet A Koç, MD

Role: STUDY_DIRECTOR

Ankara Üniversitesi Tıp Fakültesi

Locations

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Ankara University School of Medicine Department of General Surgery

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Kerem MD OZGU, MD

Role: CONTACT

+9005549886868

Facility Contacts

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Mehmet A Koç, MD

Role: primary

+905333393608

Cihangir A Akyol, MD

Role: backup

+905052653497

References

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Ferrer-Marquez M, Espinola-Cortes N, Reina-Duarte A, Granero-Molina J, Fernandez-Sola C, Hernandez-Padilla JM. Analysis and description of disease-specific quality of life in patients with anal fistula. Cir Esp (Engl Ed). 2018 Apr;96(4):213-220. doi: 10.1016/j.ciresp.2017.12.003. Epub 2018 Feb 13. English, Spanish.

Reference Type BACKGROUND
PMID: 29452968 (View on PubMed)

Kristo I, Stift A, Staud C, Kainz A, Bachleitner-Hofmann T, Chitsabesan P, Riss S. The type of loose seton for complex anal fistula is essential to improve perianal comfort and quality of life. Colorectal Dis. 2016 Jun;18(6):O194-8. doi: 10.1111/codi.13335.

Reference Type BACKGROUND
PMID: 26999764 (View on PubMed)

Ferrer-Marquez M, Espinola-Cortes N, Reina-Duarte A, Granero-Molina J, Fernandez-Sola C, Hernandez-Padilla JM. Design and Psychometric Evaluation of the Quality of Life in Patients With Anal Fistula Questionnaire. Dis Colon Rectum. 2017 Oct;60(10):1083-1091. doi: 10.1097/DCR.0000000000000877.

Reference Type BACKGROUND
PMID: 28891853 (View on PubMed)

Related Links

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https://doi.org/10.1016/j.ciresp.2017.12.003

Análisis y descripción de la calidad de vida específica en pacientes con fístula analAnalysis and description of disease-specific quality of life in patients with anal fistula

Other Identifiers

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AUG-2021-0001

Identifier Type: -

Identifier Source: org_study_id

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