Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-15

Study Completion Date

2022-01-15

Brief Summary

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Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best. Rapid sequential intubation is one of the most frequently used techniques in advanced airway management. However, anesthetic agents and paralytic agents have some concerns with some side effects. In our study, This study aimed to compare the effect of standard rapid sequential intubation protocol and application of rocuronium priming technique on the procedure time and hemodynamic profile.

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Detailed Description

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This study is a prospective, observational and randomized study conducted between 15.07.2021 and 01.12.2021 in Ankara City Hospital Emergency Medicine Clinic, which is a third-level emergency department with approximately 450,000 patient admissions per year. Patients who applied to the emergency department and needed rapid sequential intubation were included in our study. Randomization was done according to the order of arrival of the cases. The demographic characteristics of the patients included in the study and the presence of diabetes mellitus were recorded. Routine rapid sequential intubation was performed in the standard group. In the priming group, 10% of the rocuronium dose was administered approximately 3 minutes before the induction agent. Intubation time, amount of drug used, vital signs before and after intubation, and end tidal carbon dioxide level to confirm intubation were recorded.

Conditions

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Rapid Sequence Induction and Intubation Rocuronium

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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standard

standard rapid sequence intubation group (paralysis following induction)

No interventions assigned to this group

priming

group primed with rocuronium before induction

priming with rocuronium

Intervention Type DRUG

Following induction (paralysis after onset of the induction effect) in routine rapid sequence intubation protocols While paralysis is applied, it is aimed to shorten the half-life of rocuronium by administering a subparalytic dose of rocuronium approximately 3-5 minutes before induction in the priming technique

Interventions

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priming with rocuronium

Following induction (paralysis after onset of the induction effect) in routine rapid sequence intubation protocols While paralysis is applied, it is aimed to shorten the half-life of rocuronium by administering a subparalytic dose of rocuronium approximately 3-5 minutes before induction in the priming technique

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Be over the age of 18
* Need for advanced airway
* To give consent or consent to participate in the study consent of relatives of those who are unable to give

Exclusion Criteria

* Have an indication of a crush (rescue) airway
* Have one of the difficult airway predictor Look, Evaluate, Obstruction, Neck mobility criteria
* maxillofacial anomaly or trauma
* detected during laryngoscopy with a cormack-lehane score of 3 and 4 patients
* Those who have inconveniences in applying ketamine to the clinic of the patient
* with a rocuronium or ketamine allergy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes